Amoxicillin hydrochloride | 59007-60-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 内酰胺类
• 英文名称: Amoxicillin hydrochloride
• 英文别名: (2S,5R,6R)-6-[[(2R)-2-amino-2-(4-hydroxyphenyl)acetyl]amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid;hydrochloride
• CAS: 59007-60-2
• 化学式: C16H20ClN3O5S
• 分子量: 401.9
• InChiKey: YXLRVHLUTKIZFX-YWUHCJSESA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.45
• 重原子数：
  26
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.44
• 拓扑面积：
  158
• 氢给体数：
  5
• 氢受体数：
  7

文献信息

• Nitrate salts of antimicrobial agents
  申请人：——

  公开号：US20030105066A1

  公开（公告）日：2003-06-05

  Nitrate salts of antimicrobial agents for the preparation of antimicrobial medicaments, specifically antiviral, antifungal and antibacterial medicaments.

  抗菌药物的硝酸盐，用于制备抗菌药物，特别是抗病毒、抗真菌和抗细菌药物。
• [EN] NITRATE SALTS OF ANTIMICROBIAL AGENTS<br/>[FR] NITRATES D'AGENTS ANTIMICROBIENS
  申请人：NICOX SA

  公开号：WO2001054691A1

  公开（公告）日：2001-08-02

  Nitrate salts of antimicrobial agents for the preparation of antimicrobial medicaments, specifically antiviral, antifungal and antibacterial medicaments.

  硝酸盐抗微生物药剂的制备，具体包括抗病毒、抗真菌和抗菌药剂。
• Pharmaceutical compositions for controlled release delivery of biologically active compounds
  申请人：Li Yuhua

  公开号：US20060034923A1

  公开（公告）日：2006-02-16

  The present invention provides compositions and methods for the controlled release delivery of one or more biologically active compounds to a subject. Specifically, the invention provides for a pharmaceutical composition for the controlled release delivery of biologically active compounds to a subject comprising: a) a complex of a biologically active compound having at least one basic functional group and a polyanion derived from hexahydroxycyclohexane having at least two negatively charged functional groups; and b) a pharmaceutically acceptable carrier comprising a biodegradable, water-insoluble polymer. By complexing a biologically active compound with a polyanion, the tight, stable complex may be incorporated into a long-acting dosage system having a more desired drug release curve over time than that is found in the prior art. The invention also provides the methods of making such compositions and the methods of use thereof.

  本发明提供了一种控制释放给予受体体内一个或多个生物活性化合物的组合物和方法。具体而言，本发明提供了一种制药组合物，用于控制释放生物活性化合物给予受体，包括：a) 生物活性化合物的复合物，其至少具有一个碱性功能团，并且是由至少具有两个负电荷功能团的六羟基环己烷衍生的聚阴离子; 和 b) 包含可生物降解的、水不溶性聚合物的药用载体。通过将生物活性化合物与聚阴离子形成复合物，可以将紧密、稳定的复合物纳入长效剂量系统中，其具有比现有技术更理想的药物释放曲线。本发明还提供了制备这种组合物的方法和使用这种组合物的方法。
• Novel method of treatment using a high dosage regimen of amoxycillin and potassium clavulanate
  申请人：Beecham Pharmaceuticals (Pte) Limited

  公开号：EP1044680A1

  公开（公告）日：2000-10-18

  Bacterial infections may be treated using a high dosage regimen of amoxycillin and potassium clavulanate. Preferably, the dosage is provided by a bilayer tablet

  细菌感染可使用大剂量的阿莫西林和克拉维酸钾治疗。最好使用双层片剂提供剂量
• Unit dosage comprising amoxycillin and clavulanate
  申请人：Beecham Pharmaceuticals (Pte) Limited

  公开号：EP1269996A1

  公开（公告）日：2003-01-02

  Bacterial infections may be treated using a high dosage regimen of amoxycillin and potassium clavulanate. Preferably, the dosage is provided by a bilayer tablet

  细菌感染可使用大剂量的阿莫西林和克拉维酸钾治疗。最好使用双层片剂提供剂量