N-((R)-1-(4-(2,4-dimethoxybenzyl)-5-phenethyl-4H-1,2,4-triazol-3-yl)-2-(1H-indol-3-yl)ethyl)-tetrahydro-2H-pyran-4-carboxamide | 1187364-89-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-((R)-1-(4-(2,4-dimethoxybenzyl)-5-phenethyl-4H-1,2,4-triazol-3-yl)-2-(1H-indol-3-yl)ethyl)-tetrahydro-2H-pyran-4-carboxamide
• 英文别名: N-[(1R)-1-[4-[(2,4-dimethoxyphenyl)methyl]-5-(2-phenylethyl)-1,2,4-triazol-3-yl]-2-(1H-indol-3-yl)ethyl]oxane-4-carboxamide
• CAS: 1187364-89-1
• 化学式: C₃₅H₃₉N₅O₄
• 分子量: 593.726
• InChiKey: FRUUPYZQWMCLDQ-WJOKGBTCSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.8
• 重原子数：
  44
• 可旋转键数：
  12
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.34
• 拓扑面积：
  103
• 氢给体数：
  2
• 氢受体数：
  6

文献信息

• NOVEL 1,2,4-TRIAZOLE DERIVATIVES AND PROCESS OF MANUFACTURING THEREOF
  申请人：Fehrentz Jean-Alain

  公开号：US20090239877A1

  公开（公告）日：2009-09-24

  The invention provides 1,2,4-triazole compounds, compositions containing those compounds, methods of treating diseases and/or disorders with those compounds and processes of manufacturing 1,2,4-triazole compounds.

  本发明提供了1,2,4-三唑化合物、含有该化合物的组合物、使用该化合物治疗疾病和/或障碍的方法以及制造1,2,4-三唑化合物的过程。
• Novel 1,2,4-triazole derivatives and process of manufacturing thereof
  申请人：Æterna Zentaris GmbH

  公开号：EP2103602A1

  公开（公告）日：2009-09-23

  The invention discloses a process of manufacturing 1,2,4-triazole derivatives comprising steps (a) to (e). The invention further discloses novel 1,2,4-triazoie derivatives and their use as medicaments.

  本发明公开了一种制造 1,2,4-三唑衍生物的工艺，包括步骤(a)至(e)。本发明进一步公开了新型 1,2,4-三唑衍生物及其作为药物的用途。
• 1,2,4-Triazole derivatives as ghrelin analogue ligands of GHS receptors
  申请人：Æterna Zentaris GmbH

  公开号：EP2604594A1

  公开（公告）日：2013-06-19

  The invention discloses novel 1,2,4-triazole derivatives and their use as medicaments.

  本发明公开了新型 1，2，4-三唑衍生物及其作为药物的用途。
• [EN] NOVEL 1,2,4-TRIAZOLE DERIVATIVES AND PROCESS OF MANUFACTURING THEREOF<br/>[FR] NOUVEAUX DÉRIVÉS DE 1,2,4-TRIAZOLE ET LEUR PROCÉDÉ DE FABRICATION
  申请人：AETERNA ZENTARIS GMBH

  公开号：WO2009115503A1

  公开（公告）日：2009-09-24

  The invention discloses a process of manufacturing 1,2,4-triazole derivatives comprising steps (a) to (e). The invention further discloses novel 1,2,4-triazole derivatives and their use as medicaments.