5-cyano-pyridine-2-carboxylic acid [6-((R)-2-amino-5,5-difluoro-4-methyl-5,6-dihydro-4H-[1,3]oxazin-4-yl)-5-fluoro-pyridin-2-yl]-amide | 1425840-80-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 5-cyano-pyridine-2-carboxylic acid [6-((R)-2-amino-5,5-difluoro-4-methyl-5,6-dihydro-4H-[1,3]oxazin-4-yl)-5-fluoro-pyridin-2-yl]-amide
• 英文别名: N-[6-[(4R)-2-amino-5,5-difluoro-4-methyl-6H-1,3-oxazin-4-yl]-5-fluoropyridin-2-yl]-5-cyanopyridine-2-carboxamide
• CAS: 1425840-80-7
• 化学式: C₁₇H₁₃F₃N₆O₂
• 分子量: 390.324
• InChiKey: ZWUWGLTVWPXQQS-MRXNPFEDSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1
• 重原子数：
  28
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.24
• 拓扑面积：
  126
• 氢给体数：
  2
• 氢受体数：
  9

文献信息

• NOVEL OXAZINE DERIVATIVES AND THEIR USE IN THE TREATMENT OF DISEASE
  申请人：LUEOEND Rainer Martin

  公开号：US20130172331A1

  公开（公告）日：2013-07-04

  The invention relates to novel oxazine derivatives of formula (I), and pharmaceutically acceptable salts thereof, in which all of the variables are as defined in the specification, pharmaceutical compositions thereof, combinations thereof, and their use as medicaments, particularly for the treatment of Alzheimer's Disease or diabetes via inhibition of BACE-1 or BACE-2.

  本发明涉及一种新型的氧杂环衍生物，其化学式为（I），以及其药学上可接受的盐。其中，所有变量均如规范中定义的那样。本发明还涉及这些化合物的药物组成物、其组合物以及它们作为药物的用途，特别是通过抑制BACE-1或BACE-2治疗阿尔茨海默病或糖尿病。
• 2 -AMINO-4 - (PYRIDIN- 2 -YL) - 5, 6 -DIHYDRO-4H- 1, 3 -OXAZINE DERIVATIVES AND THEIR USE AS BACE-1 AND/OR BACE - 2 INHIBITORS
  申请人：Novartis AG

  公开号：EP3023423A1

  公开（公告）日：2016-05-25

  The invention relates to novel oxazine derivatives of formula (I), and pharmaceutically acceptable salts thereof, in which all of the variables are as defined in the specification, pharmaceutical compositions thereof, combinations thereof, and their use as medicaments, particularly for the treatment of Alzheimer's Disease via inhibition of BACE-1.

  本发明涉及式（I）的新型噁嗪衍生物及其药学上可接受的盐类、 其中所有变量均如说明书中所定义、其药物组合物、其组合物及其作为药物的用途，特别是通过抑制 BACE-1 治疗阿尔茨海默病的用途。
• US9163011B2
  申请人：——

  公开号：US9163011B2

  公开（公告）日：2015-10-20