1,1'-([1,1'-biphenyl]-4,4'-diyl)bis(but-3-en-1-ol) | 1448016-69-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 1,1'-([1,1'-biphenyl]-4,4'-diyl)bis(but-3-en-1-ol)
• CAS: 1448016-69-0
• 化学式: C₂₀H₂₂O₂
• 分子量: 294.393
• InChiKey: OZADYIXKLDNXHC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.57
• 重原子数：
  22.0
• 可旋转键数：
  7.0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  40.46
• 氢给体数：
  2.0
• 氢受体数：
  2.0

反应信息

• 作为产物：
  描述：

  4,4'-联苯二甲醛 、 烯丙基三氟硼酸钾 在 Amberlyst A-15 作用下， 以 二氯甲烷 、 水 为溶剂， 反应 0.67h， 以50%的产率得到1,1'-([1,1'-biphenyl]-4,4'-diyl)bis(but-3-en-1-ol)
  参考文献：
  名称：

  Allylation of aldehydes with potassium allyltrifluoroborate catalyzed by Amberlyst A-15

  摘要：

  The use of the commercially available resin Amberlyst-15 as catalyst for allylation of aldehydes by potassium allyltrifluoroborate is described. The method features the use of a commercially available catalyst, aqueous media, and the products were obtained in high yields, short reaction times, at room temperature and no further purification. The catalyst was recovered and reused up to six times in further allylation reactions without significant yield losses. B-11 NMR experiments were conducted in order to evaluate the possible mechanism pathway. The formation of tricoordinate boron species was not observed. (C) 2013 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2013.06.050