3-(4-bromo-phenyl)-2-cyano-propane | 945918-72-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 3-(4-bromo-phenyl)-2-cyano-propane
• 英文别名: 3-(4-Bromophenyl)-2-methylpropanenitrile；3-(4-bromophenyl)-2-methylpropanenitrile
• CAS: 945918-72-9
• 化学式: C₁₀H₁₀BrN
• 分子量: 224.1
• InChiKey: FDUNJTMIODMYIB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  12
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  23.8
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  (2R)-2-cyano-2-methyl-3-(4'-bromophenyl)propanoic acid 反应 0.15h， 以100%的产率得到3-(4-bromo-phenyl)-2-cyano-propane
  参考文献：
  名称：

  WO2007/88571

  摘要：

  公开号：

文献信息

• [EN] MACROCYCLIC BROAD SPECTRUM ANTIBIOTICS<br/>[FR] ANTIBIOTIQUES MACROCYCLIQUES À LARGE SPECTRE
  申请人：RQX PHARMACEUTICALS INC

  公开号：WO2018149419A1

  公开（公告）日：2018-08-23

  Provided herein are antibacterial compounds, wherein the compounds in some embodiments have broad spectrum bioactivity. In various embodiments, the compounds act by inhibition of bacterial type 1 signal peptidase (SpsB), an essential protein in bacteria. Pharmaceutical compositions and methods for treatment using the compounds described herein are also provided.

  本文提供了抗菌化合物，其中在某些实施例中，这些化合物具有广谱生物活性。在各种实施例中，这些化合物通过抑制细菌类型1信号肽酶（SpsB）发挥作用，这是细菌中的一种必需蛋白质。还提供了使用所述化合物的药物组合物和治疗方法。
• PROCESS FOR RESOLVING RACEMIC MIXTURES AND A DIASTEREOISOMERIC COMPLEX OF A RESOLVING AGENT AND AN ENANTIOMER OF INTEREST
  申请人：Napolitano Elio

  公开号：US20090292129A1

  公开（公告）日：2009-11-26

  A process for resolving a compound in racemic form comprising the following steps is described: a) reacting a compound in racemic form with a resolving agent, b) forming a diastereoisomeric complex of the resolving agent and an enantiomer of interest, c) separating the enantiomer of interest from the obtained diastereoisomer, wherein such a process is characterized in that said resolving agent is a compound of Formula (I). A diastereoisomeric complex between the resolving agent of Formula (I) and the enantiomer of interest is also described. The process according to the invention allows acid and basic racemic mixtures to be separated.

  本发明提供了一种用于分离外消旋化合物的方法，包括以下步骤：a）将外消旋化合物与分离剂反应，b）形成分离剂和所需对映体的非对映异构体复合物，c）从所得的非对映异构体中分离所需对映体。其中，所述分离剂为式（I）的化合物。本发明还描述了分离剂式（I）与所需对映体之间的非对映异构体复合物。本发明所述方法可以分离酸性和碱性外消旋混合物。
• [EN] SULFONYL BENZAMIDE DERIVATIVES AS BCL-2 INHIBITORS<br/>[FR] DÉRIVÉS DE SULFONYL BENZAMIDE UTILISÉS COMME INHIBITEURS DE BCL-2
  申请人：ASCENTAGE PHARMA SUZHOU CO LTD

  公开号：WO2022161496A1

  公开（公告）日：2022-08-04

  The present disclosure provides compounds having Formula I: and the pharmaceutically acceptable salts and solvates thereof, wherein variables are as defined as set forth in the specification. The present disclosure also provides compounds of Formula I for use to treat a disease, disorder, or condition responsive to Bcl-2 protein inhibition, particiularly Bcl-2 WT and/or Bcl-2 G101V.

  本公开提供具有式I的化合物及其药学上可接受的盐和溶剂化物，其中变量如规范中所定义。本公开还提供式I的化合物，用于治疗对Bcl-2蛋白抑制有响应的疾病，失调或情况，特别是Bcl-2 WT和/或Bcl-2 G101V。
• A PROCESS FOR RESOLVING RACEMIC MIXTURES AND A DIASTEREOISOMERIC COMPLEX OF A RESOLVING AGENT AND AN ENANTIOMER OF INTEREST
  申请人：ABIOGEN PHARMA S.p.A.

  公开号：EP1986996A2

  公开（公告）日：2008-11-05
• EXO-AZA SPIRO INHIBITORS OF MENIN-MLL INTERACTION
  申请人：Janssen Pharmaceutica NV

  公开号：EP3728260A1

  公开（公告）日：2020-10-28