Ethyl 3-(4-bromophenyl)-3-phenylprop-2-enoate | 183593-80-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: Ethyl 3-(4-bromophenyl)-3-phenylprop-2-enoate
• CAS: 183593-80-8
• 化学式: C₁₇H₁₅BrO₂
• 分子量: 331.2
• InChiKey: AFSCKQRWWSLJRZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.1
• 重原子数：
  20
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  2

文献信息

• Novel compounds, their preparation and use
  申请人：——

  公开号：US20030139473A1

  公开（公告）日：2003-07-24

  Novel compounds of the general formula (I), the use of these compounds as pharmaceutical compositions, pharmaceutical compositions comprising the compounds and methods of treatment employing these compounds and compositions. The present compounds may be useful in the treatment and/or prevention of conditions mediated by Peroxisome Proliferator-Activated Receptors (PPAR), in particular the PPAR&dgr; suptype.

  通用公式（I）的新化合物，这些化合物作为药物组合物的用途，包含这些化合物的药物组合物以及使用这些化合物和组合物的治疗方法。这些化合物可能对通过过氧化物酶体增殖激活受体（PPAR）介导的疾病的治疗和/或预防有用，特别是PPAR&dgr;亚型。
• NOVEL COMPOUNDS, THEIR PREPARATION AND USE
  申请人：Sauerberg Per

  公开号：US20090093484A1

  公开（公告）日：2009-04-09

  Novel compounds of the general formula (I), the use of these compounds as pharmaceutical compositions, pharmaceutical compositions comprising the compounds and methods of treatment employing these compounds and compositions. The present compounds are activators of PPARδ and should be useful for treating conditions mediated by the same.

  通式（I）的新化合物，这些化合物的用途为制备药物组合物，该组合物包含这些化合物并且使用这些化合物和组合物的治疗方法。这些化合物是PPARδ激活剂，应该对通过PPARδ介导的疾病有用。
• PHENOXY ACETIC ACIDS AS PPAR DELTA ACTIVATORS
  申请人：Sauerberg Per

  公开号：US20110245244A1

  公开（公告）日：2011-10-06

  Novel compounds of the general formula (I), the use of these compounds as pharmaceutical compositions, pharmaceutical compositions comprising the compounds and methods of treatment employing these compounds and compositions. The present compounds are activators of PPARδ and should be useful for treating conditions mediated by the same.

  一般式（I）的新化合物，这些化合物作为制药组合物的用途，包括这些化合物的制药组合物和使用这些化合物和组合物的治疗方法。这些化合物是PPARδ的激活剂，应该对通过PPARδ介导的疾病治疗有用。
• PHENOXY ACETIC ACIDS AND PHENYL PROPIONIC ACIDS AS PPAR DELTA AGONISTS
  申请人：High Point Pharmaceuticals, LLC

  公开号：US20140024645A1

  公开（公告）日：2014-01-23

  Phenoxy acetic acids and phenyl propionic acids and their use in treating type I diabetes, type II diabetes, impaired glucose tolerance, insulin resistance, or obesity are provided herein. The present compounds are activators of PPARδ and may be useful for treating conditions mediated by the same.

  本文提供了苯氧乙酸和苯基丙酸及其在治疗1型糖尿病、2型糖尿病、糖耐量受损、胰岛素抵抗或肥胖症方面的用途。这些化合物是PPARδ的激活剂，可能对由其介导的疾病有用。
• Phenoxy acetic acids and phenyl propionic acids as PPAR delta agonists
  申请人：vTv Therapeutics LLC

  公开号：US10471066B2

  公开（公告）日：2019-11-12

  Phenoxy acetic acids and phenyl propionic acids and their use in improving mitochondrial energy output in a subject are provided herein. The present compounds are activators of PPARδ and may be useful for treating conditions mediated by the same.

  本文提供了苯氧基乙酸和苯丙酸及其在改善受试者线粒体能量输出方面的用途。本化合物是 PPARδ 的激活剂，可用于治疗由 PPARδ 介导的疾病。