| 2961-62-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• CAS: 2961-62-8
• 化学式: C7H3I2NNaO
• 分子量: 393.9
• InChiKey: GQOMRUQZQBMANH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.09
• 重原子数：
  12
• 可旋转键数：
  0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  44
• 氢给体数：
  1
• 氢受体数：
  2

文献信息

• Enhanced production of taxanes by cell cultures of taxus species
  申请人：Phyton Inc.

  公开号：EP1398384A1

  公开（公告）日：2004-03-17

  This invention provides methods whereby taxol, baccatin III, and other taxol-like compounds, or taxanes, can be produced in very high yield from all known Taxus species, e.g. brevifolia, canadensis, cuspidata, baccata, globosa, floridana, wallichiana, media and chinensis. Particular modifications of culture conditions (i.e. media composition and operating modes) have been discovered to enhance the yield of various taxanes from cell culture of all species of Taxus. Particularly preferred enhancement agents include silver ion or complex, jasmonic acid (especially the methyl ester), auxin-related growth regulators, and inhibitors of the phenylpropanoid pathway, such as 3,4-methylenedioxy-6-nitrocinnamic acid. These enhancement agents may be used alone or in combination with one another or other yield-enhancing conditions. While the yield of taxanes from plant cell culture of T. chinensis is particularly enhanced by use of one or more of these conditions, yield of taxanes for all Taxus species has been found to benefit from use of these conditions.

  本发明提供了可从所有已知的紫杉品种（如brevifolia、canadensis、cuspidata、baccata、globosa、floridana、wallichiana、media和chinensis）中以极高产率生产紫杉醇、巴卡丁Ⅲ和其他紫杉醇类化合物或紫杉素的方法。已发现对培养条件（即培养基成分和操作模式）的特定修改可提高所有紫杉属植物细胞培养中各种紫杉素的产量。特别优选的增强剂包括银离子或银离子络合物、茉莉酸（尤其是甲酯）、与辅助素相关的生长调节剂和苯丙醇途径抑制剂，如 3,4-亚甲二氧基-6-硝基肉桂酸。这些增产剂可以单独使用，也可以相互结合或在其他增产条件下使用。虽然使用其中一种或多种条件可特别提高植物细胞培养 T. chinensis 的紫杉醇产量，但已发现使用这些条件可提高所有紫杉属植物的紫杉醇产量。
• Methods and compositions involving ALS variants with native substrate preference
  申请人：E I DU PONT DE NEMOURS AND COMPANY

  公开号：US10294487B2

  公开（公告）日：2019-05-21

  Compositions and methods comprising polynucleotides and polypeptides having ALS activity and tolerance to at least one ALS inhibitor are provided. In specific embodiments, the sequence has an increased preference for 2-ketobutyrate, when compared to an appropriate control, such as for example, HRA, and/or a preference for 2-ketobutyrate similar to a native ALS. Further provided are nucleic acid constructs, plants, plant cells, explants, seeds and grain having the ALS inhibitor tolerant sequences. Various methods of employing the ALS inhibitor tolerant sequences are provided. Such methods include methods for producing an ALS inhibitor tolerant plant, plant cell, explant or seed and methods of controlling weeds in a field containing a crop employing the plants and/or seeds disclosed herein.

  本发明提供了包含具有 ALS 活性和对至少一种 ALS 抑制剂耐受性的多核苷酸和多肽的组合物和方法。在具体的实施方案中，与适当的对照（例如 HRA）相比，该序列对 2-酮丁酸的偏好增加，和/或对 2-酮丁酸的偏好与原生 ALS 相似。此外，还提供了具有 ALS 抑制剂耐受序列的核酸构建体、植物、植物细胞、外植体、种子和谷物。还提供了采用耐 ALS 抑制剂序列的各种方法。这些方法包括生产耐 ALS 抑制剂的植物、植物细胞、外植体或种子的方法，以及在含有本文公开的植物和/或种子的作物田中控制杂草的方法。
• ENHANCED PRODUCTION OF TAXANES BY CELL CULTURES OF $i(TAXUS) SPECIES
  申请人：PHYTON, INC.

  公开号：EP0954596A1

  公开（公告）日：1999-11-10
• ENHANCED PRODUCTION OF TAXANES BY CELL CULTURES OF TAXUS SPECIES
  申请人：PHYTON, INC.

  公开号：EP0954596B1

  公开（公告）日：2006-01-04
• REVERSE-PHASE MICROCAPSULES FOR ACTIVE INGREDIENTS, SIMPLIFIED PROCESS OF MANUFACTURE THEREOF AND COMBINED FORMULATIONS WDG-CS, ZC, EC-SC AND CX
  申请人：GAT Microencapsulation AG

  公开号：EP2004718A1

  公开（公告）日：2008-12-24