(1S,2R,4R,5R,6R)-5,6-Bis-diphenylphosphanyl-bicyclo[2.2.1]heptan-2-ol | 144090-01-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (1S,2R,4R,5R,6R)-5,6-Bis-diphenylphosphanyl-bicyclo[2.2.1]heptan-2-ol
• 英文别名: (1S,2R,4R,5R,6R)-5,6-bis(diphenylphosphanyl)bicyclo[2.2.1]heptan-2-ol
• CAS: 144090-01-7
• 化学式: C₃₁H₃₀OP₂
• 分子量: 480.526
• InChiKey: NJAOHDDCSGGIBU-PXVVYZNXSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.2
• 重原子数：
  34
• 可旋转键数：
  6
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.23
• 拓扑面积：
  20.2
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  (1S,2R,4R,5R,6R)-5,6-Bis-(diphenyl-phosphinoyl)-bicyclo[2.2.1]heptan-2-ol 在 三氯硅烷 、 三乙胺 作用下， 以50%的产率得到(1S,2R,4R,5R,6R)-5,6-Bis-diphenylphosphanyl-bicyclo[2.2.1]heptan-2-ol
  参考文献：
  名称：

  Synthesis of 6-endo-hydroxy norphos, a potential ligand for construction of chiral bimetallic catalysts

  摘要：

  6-endo-hydroxy norphos has been synthesized in two steps from norphos dioxide. The key step involves hydroxymercuration with the participation of the endo P=O group. The hydroxy diphosphine is expected to be a good candidate for the synthesis of a bimetallic system where the diphosphine moiety will bind a soft metal (such as rhodium) while the OH group will provide a hard center by its transformation into an OM group (M = Ti, Al, B etc). The fixed geometry of the system should be adapted to stereoselective catalytic transformations on bifunctional substrates of defined structures.

  DOI：

  10.1016/s0957-4166(00)82181-3