Isoquinoline-3-carboxylic acid (4-amino-phenyl)-amide | 849338-04-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: Isoquinoline-3-carboxylic acid (4-amino-phenyl)-amide
• 英文别名: N-(4-Aminophenyl)-3-isoquinolinecarboxamide；N-(4-aminophenyl)isoquinoline-3-carboxamide
• CAS: 849338-04-1
• 化学式: C₁₆H₁₃N₃O
• 分子量: 263.299
• InChiKey: WSSZWXIAGMQRHG-UHFFFAOYSA-N

反应信息

• 作为反应物：
  描述：

  (±)-1-(4-氟苯基)乙基异硫氰酸 、 Isoquinoline-3-carboxylic acid (4-amino-phenyl)-amide 以 乙腈 为溶剂， 生成 isoquinoline-3-carboxylic acid (4-{3-[1-(4-fluoro-phenyl)-ethyl]-thioureido}-phenyl)-amide
  参考文献：
  名称：

  Thiourea inhibitors of herpesviruses. Part 3: Inhibitors of varicella zoster virus

  摘要：

  The preparation of alpha-methylbenzyl thioureas and their biological activity against varicella zoster virus is described. Several analogs demonstrated IC(50)s < 0.1 muM and their SAR are discussed. These compounds represent a novel class of potent and selective nonnucleoside inhibitors of varicella zoster virus. (C) 2004 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2004.06.025