13-乙基性甾-1,3,5(10)-三烯-3,16alpha,17beta-三醇 | 19882-03-2

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 类固醇和类固醇衍生物
• 中文名称: 13-乙基性甾-1,3,5(10)-三烯-3,16alpha,17beta-三醇
• 中文别名: (8R,9S,14S,16R,17R)-13-乙基-7,8,9,11,12,13,14,15,16,17-十氢-6H-环戊二烯并[a]菲-3,16,17-三酚(non-preferredname)
• 英文名称: 13β-Ethylgona-1,3,5(10)-trien-3,16α,17β-triol
• 英文别名: 18-Homoestriol；(8R,9S,13S,14S,16R,17R)-13-ethyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthrene-3,16,17-triol
• CAS: 19882-03-2
• 化学式: C₁₉H₂₆O₃
• 分子量: 302.414
• InChiKey: KMVJBESLNMZCAQ-QKDSSNGWSA-N

物化性质

• 沸点：
  383.44°C (rough estimate)
• 密度：
  1.1189 (rough estimate)

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  22
• 可旋转键数：
  1
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.68
• 拓扑面积：
  60.7
• 氢给体数：
  3
• 氢受体数：
  3

文献信息

• Pharmaceutical preparations, use of these preparations and process for increasing the biovailability of pharmaceutical substances to be administered perorally
  申请人：——

  公开号：US20040223983A1

  公开（公告）日：2004-11-11

  The invention relates to pharmaceutical preparations that contain at least one emulsifier, at least one auxiliary emulsifier and/or solvent as well as at least one lipid, characterized in that the mass ratio of emulsifier to auxiliary emulsifier and/or solvent (Smix) is 1:1 to 9:1 and the total lipid proportion is >0% (m/m), whereby this preparation at least partially inhibits at least one intestinal enzyme and/or at least one intestinal efflux system. These preparations can be used to increase the bioavailability of pharmaceutical substances that are lipophilic and/or substrates of intestinal metabolizing enzymes and/or intestinal efflux systems, especially steroids.

  本发明涉及含有至少一种乳化剂、至少一种辅助乳化剂和/或溶剂以及至少一种脂质的药物制剂，其特征在于乳化剂与辅助乳化剂和/或溶剂（Smix）的质量比为1:1至9:1，总脂质比例大于0%（m/m），从而该制剂至少部分抑制至少一种肠道酶和/或至少一种肠道外流系统。这些制剂可用于提高亲脂性和/或肠道代谢酶和/或肠道外排系统底物的药物物质（尤其是类固醇）的生物利用度。