(4-Chlorophenyl){3-[2-(thiophen-2-yl)ethenyl]-1H-pyrazol-1-yl}methanone | 387353-07-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (4-Chlorophenyl){3-[2-(thiophen-2-yl)ethenyl]-1H-pyrazol-1-yl}methanone
• 英文别名: (4-chlorophenyl)-[3-(2-thiophen-2-ylethenyl)pyrazol-1-yl]methanone
• CAS: 387353-07-3
• 化学式: C₁₆H₁₁ClN₂OS
• 分子量: 314.8
• InChiKey: OUACWQDYTFTDOF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.4
• 重原子数：
  21
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  63.1
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  1-(methylsulfonyl)-3-(2-(2-thienyl)vinyl)-1H-pyrazole 、 (3-benzhydrylpyrazol-1-yl)-(4-chlorophenyl)methanone;2-chloro-6-[4-[1-[(4-chlorophenyl)methyl]pyrazol-3-yl]phenoxy]benzonitrile;(4-chlorophenyl)-[3-[3-(4-chlorophenyl)-5-methyl-1,2-oxazol-4-yl]pyrazol-1-yl]methanone;(4-chlorophenyl)-[3-(2-methylimidazo[1,2-a]pyridin-3-yl)pyrazol-1-yl]methanone;(4-chlorophenyl)-[3-[4-methyl-2-(5-thiophen-2-ylthiophen-2-yl)-1,3-thiazol-5-yl]pyrazol-1-yl]methanone;(4-chlorophenyl)-[3-(3-phenyl-1,2-oxazol-5-yl)pyrazol-1-yl]methanone;1-(4-chlorophenyl)sulfonyl-3-(2-thiophen-2-ylethenyl)pyrazole;N-(4-chlorophenyl)-3-(2-thiophen-2-ylethenyl)pyrazole-1-carboxamide;(4-chlorophenyl)-[3-(5-thiophen-2-ylthiophen-2-yl)pyrazol-1-yl]methanone;(2,4-dichlorophenyl)-[3-[5-(2,4-difluorophenyl)furan-2-yl]pyrazol-1-yl]methanone;2,2-dimethyl-1-[3-(2-thiophen-2-ylethenyl)pyrazol-1-yl]propan-1-one;N-methyl-3-(2-thiophen-2-ylethenyl)pyrazole-1-carboxamide;N-phenyl-3-(2-thiophen-2-ylethenyl)pyrazole-1-carboxamide 生成 (4-Chlorophenyl){3-[2-(thiophen-2-yl)ethenyl]-1H-pyrazol-1-yl}methanone
  参考文献：
  名称：

  Small-molecule modulators of hepatocyte growth factor/scatter factor activities

  摘要：

  本发明涉及小分子有机化合物，具有模拟或激活肝细胞生长因子/散发因子（HGF/SF）活性的能力，或抑制或拮抗HGF/SF活性，前者可用于促进组织或器官的血管生成以促进伤口或组织愈合，或增加或恢复缺血组织如心脏心肌梗死后的血流。细胞生长或增殖的抑制对于治疗炎症性疾病如炎性关节和皮肤疾病以及增生性疾病如癌症是有益的。

  公开号：

  US06589997B2

文献信息

• Small-molecule modulators of hepatocyte growth factor/scatter factor activities
  申请人：North Shore-Long Island Jewish Health System

  公开号：US06589997B2

  公开（公告）日：2003-07-08

  The invention is directed to small organic molecules having the ability to mimic or agonize hepatocyte growth factor/scatter factor (HGF/SF) activity, or inhibit or antagonize HGF/SF activity, the former useful for promoting, for example, vascularization of tissues or organs for promoting wound or tissue healing, or augmenting or restoring blood flow to ischemic tissues such as the heart following myocardial infarction. Inhibition of cellular growth or proliferation is beneficial in the treatment, for example, of inflammatory diseases such as inflammatory joint and skin diseases, and dysproliferative diseases such as cancer.

  本发明涉及小分子有机化合物，具有模拟或激活肝细胞生长因子/散发因子（HGF/SF）活性的能力，或抑制或拮抗HGF/SF活性，前者可用于促进组织或器官的血管生成以促进伤口或组织愈合，或增加或恢复缺血组织如心脏心肌梗死后的血流。细胞生长或增殖的抑制对于治疗炎症性疾病如炎性关节和皮肤疾病以及增生性疾病如癌症是有益的。
• Small-molecule modulators of hepatocyte growth factor / scatter factor activities
  申请人：——

  公开号：US20030045559A1

  公开（公告）日：2003-03-06

  The invention is directed to small organic molecules having the ability to mimic or agonize hepatocyte growth factor/scatter factor (HGF/SF) activity, or inhibit or antagonize HGF/SF activity, the former useful for promoting, for example, vascularization of tissues or organs for promoting wound or tissue healing, or augmenting or restoring blood flow to ischemic tissues such as the heart following myocardial infarction. Inhibition of cellular growth or proliferation is beneficial in the treatment, for example, of inflammatory diseases such as inflammatory joint and skin diseases, and dysproliferative diseases such as cancer.

  该发明涉及具有模拟或激活肝细胞生长因子/散发因子（HGF/SF）活性的小有机分子，或抑制或拮抗HGF/SF活性的能力，前者可用于促进组织或器官的血管化，促进伤口或组织愈合，或增强或恢复缺血组织（例如心肌梗死后的心脏）的血流。细胞生长或增殖的抑制对于治疗炎症性疾病（如炎性关节和皮肤疾病）和增殖异常性疾病（如癌症）是有益的。