5-(2-Methyl-5-oxo-1-phenyl-pyrrolidin-2-yl)-4-oxo-pentanoic acid phenylamide | 68803-51-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 5-(2-Methyl-5-oxo-1-phenyl-pyrrolidin-2-yl)-4-oxo-pentanoic acid phenylamide
• 英文别名: 5-(2-methyl-5-oxo-1-phenylpyrrolidin-2-yl)-4-oxo-N-phenylpentanamide
• CAS: 68803-51-0
• 化学式: C₂₂H₂₄N₂O₃
• 分子量: 364.444
• InChiKey: DBKLBDLZXYKSOS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  27
• 可旋转键数：
  7
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.32
• 拓扑面积：
  66.5
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  乙酰丙酸 、 苯胺 生成 5-(2-Methyl-5-oxo-1-phenyl-pyrrolidin-2-yl)-4-oxo-pentanoic acid phenylamide
  参考文献：
  名称：

  CANDELORO V.; BOWIE J. H., AUSTRAL. J. CHEM., 1978, 31, NO 9, 2031-2037

  摘要：

  DOI：

文献信息

• [EN] PRODUCTION OF 5-METHYL-N-ARYL-2-PYRROLIDONE AND 5-METHYL-N-ALKYL-2-PYRROLIDONE BY REDUCTIVE AMINATION OF LEVULINIC ACID WITH NITRO COMPOUNDS<br/>[FR] PRODUCTION DE 5-METHYL-N-ARYL-2-PYRROLIDONE ET DE 5-METHYL-N-ALKYL-2-PYRROLIDONE PAR AMINATION REDUCTRICE D'ACIDE LEVULINIQUE AVEC DES COMPOSES NITRO
  申请人：DU PONT

  公开号：WO2004084633A1

  公开（公告）日：2004-10-07

  This invention relates to a process for producing 5-methyl-N-aryl-2-pyrrolidone, 5-methyl-N-cycloalkyl-2-pyrrolidone, and 5-methyl-N-alkyl-2-pyrrolidone by reductive amination of levulinic acid with nitro compounds utilizing a metal catalyst, which is optionally supported.

  这项发明涉及利用金属催化剂（可选支撑）通过还原胺化法将γ-戊内酸与硝基化合物反应制备5-甲基-N-芳基-2-吡咯酮、5-甲基-N-环烷基-2-吡咯酮和5-甲基-N-烷基-2-吡咯酮的方法。
• Production of 5-methyl-N-aryl-2-pyrrolidone and 5-methyl-N-cycloalkyl-2-pyrrolidone by reductive amination of levulinic acid with aryl amines
  申请人：——

  公开号：US20040192939A1

  公开（公告）日：2004-09-30

  This invention relates to a process for producing 5-methyl-N-aryl-2-pyrrolidone and 5-methyl-N-cycloalkyl-2-pyrrolidone by reductive amination of levulinic acid or its derivatives with aryl amines, ammonia or ammonium hydroxide utilizing a metal catalyst, which is optionally supported.

  本发明涉及一种生产 5-甲基-N-芳基-2-吡咯烷酮和 5-甲基-N-环烷基-2-吡咯烷酮的工艺，其方法是利用金属催化剂（可选支撑金属催化剂），将乙酰丙酸或其衍生物与芳基胺、氨或氢氧化铵进行还原胺化。
• Production of 5-methyl-N-(methyl aryl)-2-pyrrolidone, 5-methyl-N-(methyl cycloalkyl)-2-pyrrolidone and 5-methyl-N-alkyl-2-pyrrolidone by reductive amination of levulinic acid with cyano compounds
  申请人：——

  公开号：US20040204592A1

  公开（公告）日：2004-10-14

  This invention relates to a process for producing 5-methyl-N-(methyl aryl)-2-pyrrolidone, 5-methyl-N-(methyl cycloalkyl)-2-pyrrolidone and 5-methyl-N-alkyl-2-pyrrolidone by reductive amination of levulinic acid with aryl cyano compounds utilizing a metal catalyst, which is optionally supported.

  本发明涉及一种生产 5-甲基-N-(甲基芳基)-2-吡咯烷酮、5-甲基-N-(甲基环烷基)-2-吡咯烷酮和 5-甲基-N-烷基-2-吡咯烷酮的工艺，其方法是利用一种金属催化剂，将乙酰丙酸与芳基氰基化合物进行还原胺化。
• Production of 5-methyl-N-aryl-2-pyrrolidone and 5-methyl-N-alkyl-2-pyrrolidone by reductive amination of levulinic acid with nitro compounds
  申请人：——

  公开号：US20040209794A1

  公开（公告）日：2004-10-21

  This invention relates to a process for producing 5-methyl-N-aryl-2-pyrrolidone, 5-methyl-N-cycloalkyl-2-pyrrolidone, and 5-methyl-N-alkyl-2-pyrrolidone by reductive amination of levulinic acid with nitro compounds utilizing a metal catalyst, which is optionally supported.

  本发明涉及一种生产 5-甲基-N-芳基-2-吡咯烷酮、5-甲基-N-环烷基-2-吡咯烷酮和 5-甲基-N-烷基-2-吡咯烷酮的工艺，其方法是利用一种金属催化剂，将乙酰丙酸与硝基化合物进行还原胺化，该催化剂可选择性地得到支持。
• PRODUCTION OF 5-METHYL-N-ARYL-2-PYRROLIDONE AND 5- METHYL-N-CYCLOALKYL-2-PYRROLIDONE BY REDUCTIVE AMINATION OF LEVULINIC ACID WITH ARYL AMINES
  申请人：E.I. DUPONT DE NEMOURS AND COMPANY

  公开号：EP1605933A1

  公开（公告）日：2005-12-21