| 51349-87-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• CAS: 51349-87-2
• 化学式: C6H5LiNO2
• 分子量: 130.1
• InChiKey: UEJMTWHXKJKXEU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.4
• 重原子数：
  10
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  50.2
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• Methanol Carbonylation Process with Rhodium Catalyst and a Lanthanide Metal Co-Catalyst
  申请人：CELANESE INTERNATIONAL CORPORATION

  公开号：US20130102810A1

  公开（公告）日：2013-04-25

  A carbonylation process for making acetic acid using a metallic co-catalyst composition, effective as a rhodium stabilizer and/or rate promoter, at molar ratios of metal/rhodium of about 0.5 to 40. The process includes reacting methanol with carbon monoxide in the presence of a rhodium-based catalytic metal complex with about 1 to 20 weight percent methyl iodide, less than about 8 weight % water and about 0.5 to about 30 weight percent methyl acetate. The crude acetic acid is flashed and further purified. This process is stable in the absence of a lithium iodide cocatalyst, or in low concentrations of lithium iodide, with an STY greater than 10 mol/L/hr.

  一种使用金属共催化剂组合物的羰基化过程，用于制备乙酸，该组合物在金属/铑的摩尔比为约0.5至40时，有效作为铑稳定剂和/或速率促进剂。该过程包括在铑基催化金属配合物的存在下，将甲醇与一氧化碳反应，具有约1至20重量％的甲基碘化物，少于约8重量％的水和约0.5至约30重量％的乙酸甲酯。粗乙酸经闪蒸后进一步纯化。该过程在缺乏碘化锂共催化剂或低浓度碘化锂的情况下是稳定的，其STY大于10mol/L/hr。
• Methanol Carbonylation Process with Rhodium Catalyst, an Iodide Salt and a Metallic Co-Catalyst Selected from Transition Metals, Indium, Strontium, Barium, Zinc, Tin and Heteropoly Acids
  申请人：Celanese International Corporation

  公开号：US20130102809A1

  公开（公告）日：2013-04-25

  A carbonylation process for making acetic acid uses a metallic co-catalyst composition effective as a rhodium stabilizer and rate promoter at molar ratios of metal/rhodium of from about 0.5 to 30. A preferred process includes: (a) reacting methanol with a carbon monoxide feedstock in a rhodium-based catalytic reaction mixture having: (i) a rhodium catalyst metal, (ii) methyl iodide maintained from about 1 to 20 weight percent, (iii) a lithium iodide co-catalyst, (iv) a metallic co-catalyst composition, (v) water maintained from 0.1 weight percent to less than 8 weight percent, (vi) methyl acetate maintained from about 0.5 to about 30 weight percent, and (vii) acetic acid; (b) flashing crude acetic acid from the reaction mixture; and (c) purifying the crude acetic acid. This process achieves stability and a STY greater than 10 mol/L/hr, with substantially less than a theoretically equivalent inorganic iodide content corresponding to the metallic co-catalyst and lithium iodide.

  一种羰基化过程用于制造乙酸，该过程使用一种金属辅催化剂组成，其在金属/铑的摩尔比为0.5至30时有效作为铑稳定剂和速率促进剂。首选的过程包括：(a)在具有以下组分的铑基催化反应混合物中将甲醇与一种一氧化碳原料反应：(i)铑催化剂金属，(ii)维持在1至20重量％之间的甲基碘，(iii)碘化锂辅催化剂，(iv)金属辅催化剂组成，(v)维持在0.1重量％至少于8重量％的水，(vi)维持在0.5至约30重量％的乙酸甲酯，以及(vii)乙酸；(b)从反应混合物中闪蒸原油乙酸；和(c)纯化原油乙酸。该过程实现了稳定性和STY大于10 mol/L/hr，且其无机碘化物含量明显低于相应的金属辅催化剂和碘化锂的理论等效含量。
• Lithium cocrystal compositions
  申请人：Zaworotko Michael John

  公开号：US10130708B2

  公开（公告）日：2018-11-20

  2:1 cocrystals of amino acids and Li+ salts crystallize from hot water to afford water stable cationic networks based upon tetrahedral lithium cations: bilayered square grids, a lithium zeolitic metal-organic material (LiZMOM) and several lithium diamondoid metal-organic materials (LiDMOMs). The compositions may be used as a pharmaceutical for the treatment of suicidality and other disorders that require lithium to penetrate the blood brain barrier and exert therapeutic effects in the CNS. Advantageously, the novel cocrystal forms described herein may be used to lower the oral dose required to achieve therapeutic concentrations of lithium in the brain, thus reducing the peripheral toxicity and potentially broadening the therapeutic index in comparison to conventional lithium forms.

  氨基酸和锂盐的 2:1 共晶体从热水中结晶出来，形成基于四面体锂阳离子的水稳定阳离子网络：双层方格网、锂沸石金属有机材料（LiZMOM）和几种锂菱形金属有机材料（LiDMOM）。这些组合物可用作治疗自杀和其他需要锂穿透血脑屏障并在中枢神经系统中发挥治疗作用的疾病的药物。更有利的是，本文所述的新型共晶形式可用于降低口服剂量，以达到锂在大脑中的治疗浓度，从而减少外周毒性，与传统的锂形式相比，有可能扩大治疗指数。
• LITHIUM COMPOSITIONS
  申请人：University of South Florida

  公开号：EP2688575B1

  公开（公告）日：2016-03-23
• ACETIC ACID PRODUCTION BY WAY OF CARBONYLATION WITH ENHANCED REACTION AND FLASHING
  申请人：Celanese International Corporation

  公开号：EP2451766A2

  公开（公告）日：2012-05-16