| 53890-72-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• CAS: 53890-72-5
• 化学式: C6H5LiNO2
• 分子量: 130.1
• InChiKey: QYEBCCUGIKACHX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.4
• 重原子数：
  10
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  50.2
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• Methanol Carbonylation Process with Rhodium Catalyst and a Lanthanide Metal Co-Catalyst
  申请人：CELANESE INTERNATIONAL CORPORATION

  公开号：US20130102810A1

  公开（公告）日：2013-04-25

  A carbonylation process for making acetic acid using a metallic co-catalyst composition, effective as a rhodium stabilizer and/or rate promoter, at molar ratios of metal/rhodium of about 0.5 to 40. The process includes reacting methanol with carbon monoxide in the presence of a rhodium-based catalytic metal complex with about 1 to 20 weight percent methyl iodide, less than about 8 weight % water and about 0.5 to about 30 weight percent methyl acetate. The crude acetic acid is flashed and further purified. This process is stable in the absence of a lithium iodide cocatalyst, or in low concentrations of lithium iodide, with an STY greater than 10 mol/L/hr.

  一种使用金属共催化剂组合物的羰基化过程，用于制备乙酸，该组合物在金属/铑的摩尔比为约0.5至40时，有效作为铑稳定剂和/或速率促进剂。该过程包括在铑基催化金属配合物的存在下，将甲醇与一氧化碳反应，具有约1至20重量％的甲基碘化物，少于约8重量％的水和约0.5至约30重量％的乙酸甲酯。粗乙酸经闪蒸后进一步纯化。该过程在缺乏碘化锂共催化剂或低浓度碘化锂的情况下是稳定的，其STY大于10mol/L/hr。
• Methanol Carbonylation Process with Rhodium Catalyst, an Iodide Salt and a Metallic Co-Catalyst Selected from Transition Metals, Indium, Strontium, Barium, Zinc, Tin and Heteropoly Acids
  申请人：Celanese International Corporation

  公开号：US20130102809A1

  公开（公告）日：2013-04-25

  A carbonylation process for making acetic acid uses a metallic co-catalyst composition effective as a rhodium stabilizer and rate promoter at molar ratios of metal/rhodium of from about 0.5 to 30. A preferred process includes: (a) reacting methanol with a carbon monoxide feedstock in a rhodium-based catalytic reaction mixture having: (i) a rhodium catalyst metal, (ii) methyl iodide maintained from about 1 to 20 weight percent, (iii) a lithium iodide co-catalyst, (iv) a metallic co-catalyst composition, (v) water maintained from 0.1 weight percent to less than 8 weight percent, (vi) methyl acetate maintained from about 0.5 to about 30 weight percent, and (vii) acetic acid; (b) flashing crude acetic acid from the reaction mixture; and (c) purifying the crude acetic acid. This process achieves stability and a STY greater than 10 mol/L/hr, with substantially less than a theoretically equivalent inorganic iodide content corresponding to the metallic co-catalyst and lithium iodide.

  一种羰基化过程用于制造乙酸，该过程使用一种金属辅催化剂组成，其在金属/铑的摩尔比为0.5至30时有效作为铑稳定剂和速率促进剂。首选的过程包括：(a)在具有以下组分的铑基催化反应混合物中将甲醇与一种一氧化碳原料反应：(i)铑催化剂金属，(ii)维持在1至20重量％之间的甲基碘，(iii)碘化锂辅催化剂，(iv)金属辅催化剂组成，(v)维持在0.1重量％至少于8重量％的水，(vi)维持在0.5至约30重量％的乙酸甲酯，以及(vii)乙酸；(b)从反应混合物中闪蒸原油乙酸；和(c)纯化原油乙酸。该过程实现了稳定性和STY大于10 mol/L/hr，且其无机碘化物含量明显低于相应的金属辅催化剂和碘化锂的理论等效含量。
• LITHIUM CO-CRYSTALS FOR TREATMENT OF NEUROPSYCHIATRIC DISORDERS
  申请人：TAN JUN

  公开号：US20160339055A1

  公开（公告）日：2016-11-24

  The invention concerns methods and compositions for treating a neuropsychiatric disorder, wherein the method comprises administering an effective amount of a co-crystal of lithium to a subject in need thereof, wherein the co-crystal comprises lithium, or a pharmaceutically acceptable salt thereof, and an amino acid.

  本发明涉及治疗神经精神障碍的方法和组合物，其中该方法包括向需要该治疗的对象施用有效量的锂的共晶体，该共晶体包括锂或其药学上可接受的盐和氨基酸。
• Process for producing a polyarylene sulfide
  申请人：Tosoh Corporation

  公开号：EP0272903A2

  公开（公告）日：1988-06-29

  A polyarylene sulfide having a high molecular weight, a high purity, good color tone and good heat sta­bility is produced by carrying out a polymerization reaction between a dihalogenated aromatic compound and a sulfur source in an organic amide solvent and in the presence of an alkali metal salt of pyridine-carboxylic acid. Such a poly­arylene sulfide is very useful for utilization in electronic components, automotive parts, etc.

  在有机酰胺溶剂中，在吡啶-羧酸的碱金属盐存在下，通过二卤化芳香族化合物和硫源之间的聚合反应，可制得分子量高、纯度高、色调好、热稳定性好的聚芳基硫醚。这种聚芳硫醚非常适用于电子元件、汽车零件等。
• Agent exhibiting anti-stress, anxiolytic and anti-depression activity, and composition based thereon
  申请人：OBSHCHESTVO S OGRANICHENNOY OTVETSTVENNOSTYU “NORMOFARM”

  公开号：US10456373B2

  公开（公告）日：2019-10-29

  The agent with antistress, anxiolytic and antidepressant activity and a composition based on it. The invention relates to the field of pharmaceutics, particularly to chemical compounds based on lithium salts, namely to substances with antistress, anxiolytic and antidepressant activity and can be used in medicine, veterinary medicine, and the pharmaceutical industry. The invention discovers the possibility of using lithium ascorbate as an agent with antistress, anxiolytic and antidepressant activity. The claimed composition with antistress, anxiolytic and antidepressant activity, including a lithium salt, contains pyridoxine hydrochloride, thiamine mononitrate and lithium ascorbate as a lithium salt. The use of lithium ascorbate as an agent with antistress, anxiolytic and antidepressant action and the composition based on it, enables to expand the assortment of the agents for indicated administration. At the same time, the claimed agents have low toxicity and high efficacy.

  具有抗抑郁、抗焦虑和抗抑郁活性的药剂及以其为基础的组合物。本发明涉及医药学领域，特别是基于锂盐的化合物，即具有抗抑郁、抗焦虑和抗抑郁活性的物质，可用于医学、兽医学和制药业。本发明发现了将抗坏血酸锂用作具有抗抑郁、抗焦虑和抗抑郁活性的制剂的可能性。所声称的具有抗抑郁、抗焦虑和抗抑郁活性的组合物，包括一种锂盐，含有盐酸吡哆醇、单硝酸硫胺素和作为锂盐的抗坏血酸锂。使用抗坏血酸锂作为具有抗抑郁、抗焦虑和抗抑郁作用的制剂以及以其为基础的组合物，可以扩大用于指定用药的制剂种类。同时，所述制剂具有低毒性和高效性。