N-sec-butyl-N’-(methylsulfonyl)phthalamide | 1465802-96-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-sec-butyl-N’-(methylsulfonyl)phthalamide
• CAS: 1465802-96-3
• 化学式: C₁₃H₁₈N₂O₄S
• 分子量: 298.363
• InChiKey: OMMXOSVUDZKGTP-UHFFFAOYSA-N

物化性质

• 密度：
  1.237±0.06 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.9
• 重原子数：
  20.0
• 可旋转键数：
  5.0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  92.34
• 氢给体数：
  2.0
• 氢受体数：
  4.0

反应信息

• 作为产物：
  描述：

  仲丁胺 、 N-Methylsulfonylphthalimid 以 二氯甲烷 为溶剂， 以65%的产率得到N-sec-butyl-N’-(methylsulfonyl)phthalamide
  参考文献：
  名称：

  Synthesis and evaluation of some variants of the Nefkens’ reagent

  摘要：

  A series of N-substituted phthalimides have been prepared in an effort to explore synthetic variants of the Nefkens' reagent. Three N-acylphthalimides [R = -CH3, -CH2CH3, and -C(CH3)(3)] were prepared and employed for the protection of a series of representative amines. In addition, an N-methanesulfonylphthalimide and N-(diethylphosphoryl)phthalimide were also prepared. It was determined that among the phthalimides that were prepared N-propanoylphthalimide was the most effective reagent for the protection reaction. (C) 2013 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2013.08.066