7-Phenylpyrido<4,3-d>pyrimidin-2,4(1H,3H)-dion | 61102-62-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 7-Phenylpyrido<4,3-d>pyrimidin-2,4(1H,3H)-dion
• 英文别名: 7-phenyl-1H-pyrido[4,3-d]pyrimidine-2,4-dione
• CAS: 61102-62-3
• 化学式: C₁₃H₉N₃O₂
• 分子量: 239.233
• InChiKey: RJRJHOJROYFYKH-UHFFFAOYSA-N

反应信息

• 作为反应物：
  描述：

  吗啉 、 7-Phenylpyrido<4,3-d>pyrimidin-2,4(1H,3H)-dion 生成 4,4′-(7-phenylpyrido[4,3-d]pyrimidin-2,4-diyl)dimorpholine
  参考文献：
  名称：

  Structure-activity study of diuretic azanaphthalene derivatives.

  摘要：

  Regression analysis by the Free-Wilson technique was applied to estimate the contribution of substituents on azanaphthalene skeletons to diuretic activity of pyrimido [4, 5-d] pyridazine and pyrido [3, 4-d] pyridazine derivatives. In the former group, one of the most preferable compounds was 2-phenyl-5, 8-dimorpholinopyrimido [4, 5-d] pyridazine and that in the latter group proved to be 1, 4-dimorpholine-7-phenylpyrido [3, 4-d] pyridazine. Subsequently, electron density distributions on a variety of azanaphthalene skeletons were calculated by extended Huckel Theory calculation. Linear multiple regression analysis to find a correlation between diuretic activity and electron density at some positions of azanaphthalene skeletons suggested that the diuretic activity might be influenced largely by electronic structures at the ring junction.

  DOI：

  10.1248/cpb.24.2078