1-(2-fluorophenyl)butan-2-ol | 1178426-45-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 1-(2-fluorophenyl)butan-2-ol
• CAS: 1178426-45-3
• 化学式: C₁₀H₁₃FO
• 分子量: 168.211
• InChiKey: TWLXYWUREJJDKD-UHFFFAOYSA-N

物化性质

• 沸点：
  237.9±15.0 °C(Predicted)
• 密度：
  1.068±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  12
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  20.2
• 氢给体数：
  1
• 氢受体数：
  2

文献信息

• Novel phosphine compound, transition metal complex containing the same phosphine compound as ligand and asymmetric synthesis catalyst containing the complex
  申请人：——

  公开号：US20030144139A1

  公开（公告）日：2003-07-31

  A phosphine compound of formula (1) 1 and a phosphine compound of formula (2) 2 a transition metal complex having the phosphine compound as a ligand and a catalyst for asymmetric hydrogenation including the transition metal complex.

  一种化学式为(1)的膦化合物和一种化学式为(2)的膦化合物，其中所述膦化合物作为配体，形成一种过渡金属配合物，并且所述过渡金属配合物是一种不对称氢化反应的催化剂。
• Antifungal carbinols
  申请人：E.I. DU PONT DE NEMOURS AND COMPANY

  公开号：EP0321211A1

  公开（公告）日：1989-06-21

  Antifungal carbinols having the formula wherein: R and R¹ are independently H or CH₃; X and Y¹ are independently H, 1 to 3 halogens or CF₃; and X′ and Y are independently H, CH₃, CF₃, OCF₂H, OCH₃ or SCH₃ and their agriculturally and pharmaceutically suitable salts are useful as plant disease control agents. The compounds may be made e.g. by reacting an appropriate oxirane of formula: with triazole or its alkali metal salt.

  具有以下式子的抗真菌醇：其中：R和R¹分别为H或CH₃；X和Y¹分别为H，1至3个卤素或CF₃；X′和Y分别为H，CH₃，CF₃，OCF₂H，OCH₃或SCH₃，并且它们的农药和药用盐对于植物病害控制剂是有用的。该化合物可以通过将适当的环氧化物与三唑或其碱金属盐反应制备而成。
• SIX-MEMBERED HETEROCYCLIC COMPOUND AND THE USE THEREOF
  申请人：Asahi Kasei Pharma Corporation

  公开号：EP1847533A1

  公开（公告）日：2007-10-24

  A compound represented by the general formula (I) or a salt thereof: [T represents oxygen atom and the like; V represents CH2 and the like; RO1 to RO4 represent hydrogen atom and the like; A represents a linear alkylene group or linear alkenylene group having 2 to 8 carbon atoms and the like; D represents carboxyl group and the like; X represents ethylene group, trimethylene group and the like; E represents -CH(OH)- group and the like; and W represent -U1-(RW1)(RW2)-U2-U3 group (U1 represents a single bond, an alkylene group having 1 to 4 carbon atoms and the like; RW1 and RW2 represent hydrogen atom and the like; U2 represents a single bond, an alkylene group having 1 to 4 carbon atoms and the like; and U3 represent an alkyl group having 1 to 8 carbon atoms and the like), or a residue of a carbon ring or heterocyclic compound], which can be utilized as an active ingredient of medicaments effective for prophylactic and/or therapeutic treatment of skeletal diseases such as osteoporosis and fracture, glaucoma, ulcerative colitis and the like.

  通式 (I) 所代表的化合物或其盐： [T 代表氧原子等；V 代表 CH2 等；RO1 至 RO4 代表氢原子等；A 代表具有 2 至 8 个碳原子的直链烯基或直链烯基等；D 代表羧基等；X 代表乙烯基、三亚甲基等；E 代表-CH(OH)- 基等；W 代表-U1-(RW1)(RW2)-U2-U3 基（U1 代表单键、具有 1 至 4 个碳原子的亚烷基等）；RW1 和 RW2 代表氢原子等；U2 代表单键、具有 1 至 4 个碳原子的亚烷基等；U3 代表具有 1 至 8 个碳原子的烷基等），或碳环或杂环化合物的残基]，可用作有效预防和/或治疗骨质疏松症和骨折等骨骼疾病、青光眼、溃疡性结肠炎等疾病的药物的活性成分。
• Novel phosphine compound, transition metal complex containing said compound as ligand and asymetric synthesis catalyst containing said complex
  申请人：Takasago International Corporation

  公开号：EP1334976B1

  公开（公告）日：2006-03-08
• US6717016B2
  申请人：——

  公开号：US6717016B2

  公开（公告）日：2004-04-06