[4-(2-methoxy-ethoxy)-benzyl]-[1-(3-ethynyl-phenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-yl]-amine | 1175085-91-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: [4-(2-methoxy-ethoxy)-benzyl]-[1-(3-ethynyl-phenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-yl]-amine
• 英文别名: 1-(3-ethynylphenyl)-N-[[4-(2-methoxyethoxy)phenyl]methyl]pyrazolo[3,4-d]pyrimidin-4-amine
• CAS: 1175085-91-2
• 化学式: C₂₃H₂₁N₅O₂
• 分子量: 399.452
• InChiKey: YRPCCNXNNXKKDJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.7
• 重原子数：
  30
• 可旋转键数：
  9
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  74.1
• 氢给体数：
  1
• 氢受体数：
  6

文献信息

• NOVEL PYRAZOLO [3, 4 -D] PYRIMIDINE DERIVATIVES AS ANTI-CANCER AGENTS
  申请人：Konakanchi Durga Prasad

  公开号：US20100298351A1

  公开（公告）日：2010-11-25

  The invention relates to substituted pyrazolo[3,4-d]pyrimidine derivatives of the Formula-(I), or pharmaceutically-acceptable salts thereof, which possess anti-proliferative activity such as anti-cancer activity and are accordingly useful in methods of treatment of the human or animal body. The invention also relates to processes for the manufacture of substituted pyrazolo[3,4-d]pyrimidine derivatives, to pharmaceutical compositions containing the compound and to its use in the manufacture of medicaments for the production of an anti-proliferative effect in a warm-blooded animal such as man.

  该发明涉及式(I)的取代吡唑并[3,4-d]嘧啶衍生物或其药学上可接受的盐，其具有抗增殖活性，如抗癌活性，并因此在人体或动物体的治疗方法中有用。该发明还涉及制备取代吡唑并[3,4-d]嘧啶衍生物的方法，含有该化合物的药物组合物，以及其在制造药物时用于在诸如人类之类的温血动物体内产生抗增殖效果的用途。
• US8349847B2
  申请人：——

  公开号：US8349847B2

  公开（公告）日：2013-01-08
• [EN] NOVEL PYRAZOLO [3, 4 -D] PYRIMIDINE DERIVATIVES AS ANTI -CANCER AGENTS<br/>[FR] NOUVEAUX DÉRIVÉS DE PYRAZOLO [3, 4 -D] PYRIMIDINE EN TANT QU'AGENTS ANTICANCÉREUX
  申请人：NATCO PHARMA LTD

  公开号：WO2009098715A2

  公开（公告）日：2009-08-13

  The invention relates to substituted pyrazolo [3,4-d] pyrimidine derivatives of the Formula-(I), or pharmaceutically-acceptable salts thereof, which possess anti-proliferative activity such as anti-cancer activity and are accordingly useful in methods of treatment of the human or animal body. The invention also relates to processes for the manufacture of substituted pyrazolo [3,4-d] pyrimidine derivatives, to pharmaceutical compositions containing the compound and to its use in the manufacture of medicaments for the production of an anti- proliferative effect in a warm-blooded animal such as man.