1-(3-chloro-phenyl)-5-cyclohexylimino-3,3-dimethyl-4-(4-methyl-piperazin-1-yl)-pyrrolidin-2-one | 7776-81-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯烷类
• 英文名称: 1-(3-chloro-phenyl)-5-cyclohexylimino-3,3-dimethyl-4-(4-methyl-piperazin-1-yl)-pyrrolidin-2-one
• 英文别名: 1-(3-Chlorophenyl)-5-cyclohexylimino-3,3-dimethyl-4-(4-methylpiperazin-1-yl)pyrrolidin-2-one
• CAS: 7776-81-0
• 化学式: C₂₃H₃₃ClN₄O
• 分子量: 416.994
• InChiKey: XXJSDCDVELQOLS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.1
• 重原子数：
  29
• 可旋转键数：
  3
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.65
• 拓扑面积：
  39.2
• 氢给体数：
  0
• 氢受体数：
  4

文献信息

• 4-(PIPERRAZIN-1-YL)-PYRROLIDIN-2-ONE COMPOUNDS AS MONOACYLGLYCEROL LIPASE (MAGL) INHIBITORS
  申请人：TAKEDA PHARMACEUTICAL COMPANY LIMITED

  公开号：US20160318864A1

  公开（公告）日：2016-11-03

  The present invention aims to provide a compound having an MAGL inhibitory action, and useful as a prophylactic or therapeutic agent for neurodegenerative diseases (e.g., Alzheimer's disease, Huntington's disease, Parkinson's disease, amyotrophic lateral sclerosis, traumatic brain injury, glaucoma, multiple sclerosis and the like), anxiety disorder, pain (e.g., inflammatory pain, carcinomatous pain, nervous pain and the like), epilepsy and the like. The present invention relates to a compound represented by the formula (I): wherein each symbol is as described in the DESCRIPTION, or a salt thereof.

  本发明旨在提供一种具有MAGL抑制作用的化合物，可用作神经退行性疾病（如阿尔茨海默病、亨廷顿病、帕金森病、肌萎缩侧索硬化、创伤性脑损伤、青光眼、多发性硬化等）、焦虑症、疼痛（如炎症性疼痛、癌症性疼痛、神经性疼痛等）、癫痫等疾病的预防或治疗剂。本发明涉及一种由下式（I）表示的化合物：其中每个符号如描述中所述，或其盐。
• US9624170B2
  申请人：——

  公开号：US9624170B2

  公开（公告）日：2017-04-18