2-chloro-benzenethiol; potassium salt | 67880-29-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-chloro-benzenethiol; potassium salt
• 英文别名: Potassium;2-chlorobenzenethiolate
• CAS: 67880-29-9
• 化学式: C₆H₄ClS*K
• 分子量: 182.715
• InChiKey: RDTFNDRIFMSKNV-UHFFFAOYSA-M

计算性质

• 辛醇/水分配系数(LogP)：
  -0.75
• 重原子数：
  9
• 可旋转键数：
  0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  1
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  2-chloro-benzenethiol; potassium salt 在 盐酸 、 1,2-丙二醇 作用下， 以 乙醇 为溶剂， 生成 5-((2-chlorophenyl)thio)thiazol-2-amine
  参考文献：
  名称：

  Mahajanshetti,C.S. et al., Journal of the Indian Chemical Society, 1963, vol. 40, p. 921 - 924

  摘要：

  DOI：

文献信息

• Novel olefin metathesis catalysts
  申请人：Bergen Teknologioverforing AS

  公开号：EP2428269A1

  公开（公告）日：2012-03-14

  The present invention refers to novel ruthenium- and osmium-based catalysts for olefin metathesis reactions, particularly to catalysts having stereoselective properties. Z-selectivity is obtained by utilising two monoanionic ligands of very different steric requirement. In olefin metathesis reactions these catalysts selectively provide the Z-isomer of disubstituted olefinic products.

  本发明涉及用于烯烃交换反应的新型钌和锇基催化剂，特别是具有立体选择性特性的催化剂。通过利用两种具有非常不同立体要求的单阴离子配体来获得Z-选择性。在烯烃交换反应中，这些催化剂可以选择性地提供二取代烯烃产物的Z异构体。
• Thio- and Oxoflavopiridols, Cyclin-Dependent Kinase 1-Selective Inhibitors:  Synthesis and Biological Effects
  作者：Kyoung Soon Kim、John S. Sack、John S. Tokarski、Ligang Qian、Sam T. Chao、Leslie Leith、Yolanda F. Kelly、Raj N. Misra、John T. Hunt、S. David Kimball、William G. Humphreys、Barris S. Wautlet、Janet G. Mulheron、Kevin R. Webster

  DOI：10.1021/jm000231g

  日期：2000.11.1

  Flavopiridol analogues, thio- and oxoflavopiridols which contain a sulfur (16) or oxygen (18) atom linker between a chromone ring and the hydrophobic side chain, are selective cyclin-dependent kinase 1 (CDK1) inhibitors with an IC50 Of 110 and 130 nM. These analogues were prepared from key intermediate 7 by substituting the ethyl sulfoxide. Enantio pure intermediate piperidone 10 was obtained from the racemic piperidone 8 via a very efficient "dynamic kinetic resolution" in 76% yield. Hydrophobic side chains such as chlorophenyl or tert-butyl produced potent CDK1 inhibitory activity, while hydrophilic side chains such as pyrimidine or aniline caused a severe reduction in CDK inhibitory activity. These analogues are competitive inhibitors with respect to ATP, and therefore activity was dependent upon the CDK subunit without being affected by the cyclin subunit or protein substrate. Thio- and oxoflavopiridols 16 and 18 are not only selective within the CDK family but also discriminated between unrelated serine/threonine and tyrosine protein kinases. CDK1 selective thio- and oxoflavopiridol analogues inhibit the colony-forming ability of multiple human tumor cell lines and possess a unique antiproliferative profile in comparison to flavopiridol.
• Mahajanshetti,C.S. et al., Journal of the Indian Chemical Society, 1963, vol. 40, p. 921 - 924
  作者：Mahajanshetti,C.S. et al.

  DOI：——

  日期：——