3-(2-hydroxyethyl)-3-methyl-2-Piperazinone | 890926-95-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯烷类
• 英文名称: 3-(2-hydroxyethyl)-3-methyl-2-Piperazinone
• 英文别名: 3-(2-hydroxyethyl)-3-methylpiperazin-2-one
• CAS: 890926-95-1
• 化学式: C₇H₁₄N₂O₂
• 分子量: 158.2
• InChiKey: XWCRILDQUYPZPW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.2
• 重原子数：
  11
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.86
• 拓扑面积：
  61.4
• 氢给体数：
  3
• 氢受体数：
  3

文献信息

• Urea inhibitors of MAP kinases
  申请人：Michelotti Luis Enrique

  公开号：US20060167247A1

  公开（公告）日：2006-07-27

  The present invention is directed to a compound having the formula wherein R 1 , R 2 , G, and Q are defined herein. The compounds of the present invention are useful as inhibitors of protein kinases such as MAP kinases, in particular p38 kinases. The present invention is also directed to compositions comprising a compound according to the above formula. The compounds and compositions described herein are useful for treating and preventing an inflammatory condition or disease. The present invention is also directed to a method of treating or preventing a protein kinase-mediated condition.

  本发明涉及一种化合物，其具有以下式子：其中R1、R2、G和Q在此处定义。本发明的化合物可用作蛋白激酶的抑制剂，例如MAP激酶，特别是p38激酶。本发明还涉及包含上述式子化合物的组合物。本发明所描述的化合物和组合物可用于治疗和预防炎症状况或疾病。本发明还涉及一种治疗或预防蛋白激酶介导病症的方法。
• UREA INHIBITORS OF MAP KINASES
  申请人：Locus Pharmaceuticals, Inc.

  公开号：EP1828169A2

  公开（公告）日：2007-09-05
• US7741479B2
  申请人：——

  公开号：US7741479B2

  公开（公告）日：2010-06-22
• [EN] UREA INHIBITORS OF MAP KINASES<br/>[FR] INHIBITEURS URÉE DE MAP KINASES
  申请人：LOCUS PHARMACEUTICALS INC

  公开号：WO2006062982A2

  公开（公告）日：2006-06-15

  [EN] The present invention is directed to a compound having the formula (I) wherein R¹, R², G, and Q are defined herein. The compounds of the present invention are useful as inhibitors of protein kinases such as MAP Kinases, in particular p38 kinases. The present invention is also directed to compositions comprising a compound according to the above formula. The compounds and compositions described herein are useful for treating and preventing an inflammatory condition or disease. The present invention is also directed to a method of treating or preventing a protein kinase-mediated condition.
  [FR] Composé de formule (I) dans laquelle R¹, R², G et Q sont définis dans le descriptif. Lesdits composés sont utiles en tant qu'inhibiteurs de protéine kinases telles que les MAP kinases, en particulier les p38 kinases. La présente invention concerne également des compositions contenant un composé de formule ci-dessus. Les composés et compositions décrits sont utiles pour traiter et prévenir des états ou maladies inflammatoires. La présente invention concerne en outre une méthode de traitement ou de prévention d'un état pathologique à médiation par les protéine kinases.