Fmoc-Lys(Boc-Ser(tBu)-Ahx)-OH | 876313-22-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 芴
• 英文名称: Fmoc-Lys(Boc-Ser(tBu)-Ahx)-OH
• CAS: 876313-22-3
• 化学式: C₃₉H₅₆N₄O₉
• 分子量: 724.895
• InChiKey: BDNCWCIBBQYDQJ-ACHIHNKUSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.65
• 重原子数：
  52.0
• 可旋转键数：
  19.0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.56
• 拓扑面积：
  181.39
• 氢给体数：
  5.0
• 氢受体数：
  8.0

反应信息

• 作为反应物：
  描述：

  Fmoc-Lys(Boc-Ser(tBu)-Ahx)-OH 在 sodium periodate 、 acetate buffer 、 三氟乙酸 作用下， 反应 2.0h， 生成 Fmoc-Lys(OCHCO-Ahx)-OH
  参考文献：
  名称：

  Design and synthesis of cyclic and linear peptide-agarose tools for baiting interacting protein partners of GPCRs

  摘要：

  A ligation strategy for the synthesis of cyclic and linear peptides covalently linked to agarose beads designed as baits to identify new interacting partners of intracellular loops of the V2 vasopressin receptor, a member of the G-protein-coupled receptor family, is reported. The peptide-resin conjugates were subsequently shown to interact specifically with a fraction of proteins present in cellular lysates. (c) 2005 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2005.10.061
• 作为产物：
  描述：

  Fmoc-Lys(Boc-Ahx)-OMe 在 sodium hydroxide 、 (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate 、 N,N-二异丙基乙胺 、 三氟乙酸 、 calcium chloride 作用下， 以 二氯甲烷 、 异丙醇 为溶剂， 生成 Fmoc-Lys(Boc-Ser(tBu)-Ahx)-OH
  参考文献：
  名称：

  Design and synthesis of cyclic and linear peptide-agarose tools for baiting interacting protein partners of GPCRs

  摘要：

  A ligation strategy for the synthesis of cyclic and linear peptides covalently linked to agarose beads designed as baits to identify new interacting partners of intracellular loops of the V2 vasopressin receptor, a member of the G-protein-coupled receptor family, is reported. The peptide-resin conjugates were subsequently shown to interact specifically with a fraction of proteins present in cellular lysates. (c) 2005 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2005.10.061