| 1676078-89-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• CAS: 1676078-89-9
• 化学式: C11H12Cl2N2NaO5
• 分子量: 346.12
• InChiKey: VUVHHBOLFJNPBQ-VTLYIQCISA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.53
• 重原子数：
  21
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  115
• 氢给体数：
  3
• 氢受体数：
  5

文献信息

• Human EPO mimentic hinge core mimetibodies, compositions, methods and uses
  申请人：Centocor Ortho Biotech Inc.

  公开号：EP2123675A2

  公开（公告）日：2009-11-25

  The present invention relates to at least one novel human EPO mimetic hinge core mimetibody or specified portion or variant, including isolated nucleic acids that encode at least one EPO mimetic hinge core mimetibody or specified portion or variant, EPO mimetic hinge core mimetibody or specified portion or variants, vectors, host cells, transgenic animals or plants, and methods of making and using thereof, including therapeutic compositions, methods and devices.

  本发明涉及至少一种新型人EPO拟铰链核心拟态抗体或特定部分或变体，包括编码至少一种EPO拟铰链核心拟态抗体或特定部分或变体的分离核酸、EPO拟铰链核心拟态抗体或特定部分或变体、载体、宿主细胞、转基因动物或植物及其制造和使用方法，包括治疗组合物、方法和装置。
• Anti-IL-23 antibodies, compositions, methods and uses
  申请人：Janssen Biotech, Inc.

  公开号：EP2452694A1

  公开（公告）日：2012-05-16

  An anti-IL-23p19 antibody, including isolated nucleic acids that encode at least one anti-IL-23p19 antibody, vectors, host cells, transgenic animals or plants, and methods of making and using thereof have applications in diagnostic and/or therapeutic compositions, methods and devices.

  抗IL-23p19抗体，包括编码至少一种抗IL-23p19抗体的分离核酸、载体、宿主细胞、转基因动物或植物，及其制造和使用方法可应用于诊断和/或治疗组合物、方法和装置。
• Anti-IL-6 antibodies, compositions, methods and uses
  申请人：Janssen Biotech, Inc.

  公开号：EP2842968A1

  公开（公告）日：2015-03-04

  An anti-IL-6 antibody, including isolated nucleic acids that encode at least one anti-IL-6 antibody, vectors, host cells, transgenic animals or plants, and methods of making and using thereof have applications in diagnostic and/or therapeutic compositions, methods and devices.

  抗IL-6抗体，包括编码至少一种抗IL-6抗体的分离核酸、载体、宿主细胞、转基因动物或植物，及其制造和使用方法可应用于诊断和/或治疗组合物、方法和设备中。
• HUMAN ANTI-IL-23 ANTIBODIES, COMPOSITIONS, METHOD AND USES
  申请人：Janssen Biotech, Inc.

  公开号：EP3219328A1

  公开（公告）日：2017-09-20

  A human anti-IL-23p19 antibody, including isolated nucleic acids that encode at least one anti-IL-23p19 antibody, vectors, host cells, and methods of making and using thereof have applications in diagnostic and/or therapeutic compositions, methods and devices.

  一种人类抗IL-23p19抗体，包括编码至少一种抗IL-23p19抗体的分离核酸、载体、宿主细胞及其制造和使用方法，可应用于诊断和/或治疗组合物、方法和设备中。
• ANTI-IL23 ANTIBODIES, COMPOSITIONS, METHODS AND USES
  申请人：Janssen Biotech, Inc.

  公开号：EP3501537A1

  公开（公告）日：2019-06-26

  An anti-IL-23p19 antibody, including isolated nucleic acids that encode at least one anti-IL-23p19 antibody, vectors, host cells, transgenic animals or plants, and methods of making and using thereof have applications in diagnostic and/or therapeutic compositions, methods and devices.

  抗IL-23p19抗体，包括编码至少一种抗IL-23p19抗体的分离核酸、载体、宿主细胞、转基因动物或植物，及其制造和使用方法可应用于诊断和/或治疗组合物、方法和装置。