ethyl N-{4-[2-(4-{[amino(imino)methyl]amino}phenyl)ethyl]-5-[4-(methylsulfonyl)benzyl]-1,3-thiazol-2-yl}carbamate | 737824-70-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: ethyl N-{4-[2-(4-{[amino(imino)methyl]amino}phenyl)ethyl]-5-[4-(methylsulfonyl)benzyl]-1,3-thiazol-2-yl}carbamate
• 英文别名: ethyl N-[4-[2-[4-(diaminomethylideneamino)phenyl]ethyl]-5-[(4-methylsulfonylphenyl)methyl]-1,3-thiazol-2-yl]carbamate
• CAS: 737824-70-3
• 化学式: C₂₃H₂₇N₅O₄S₂
• 分子量: 501.63
• InChiKey: VBEBQAVACYMCMQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  34
• 可旋转键数：
  10
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.26
• 拓扑面积：
  186
• 氢给体数：
  3
• 氢受体数：
  7

文献信息

• METHOD FOR TREATING VASCULAR HYPERPERMEABLE DISEASE
  申请人：R-Tech Ueno, Ltd.

  公开号：EP1608365B1

  公开（公告）日：2013-10-02
• Aqueous Composition Comprising Thiazole Derivative
  申请人：Ueno Ryuji

  公开号：US20070208068A1

  公开（公告）日：2007-09-06

  The present invention provides an aqueous composition comprising a thiazole derivative of the formula (I): R 1 —NH—X—Y-Z (I) wherein each symbol is as defined above, or a pharmaceutically acceptable salt thereof, and an additive selected from the group consisting of polyol, sugar, sugar alcohol, boric acid or its salt, and water. The aqueous composition is very stable and can be stored for a long time.