N-Methyl-5-chlormethyl-2-pyrrolidon | 66769-85-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯烷类
• 英文名称: N-Methyl-5-chlormethyl-2-pyrrolidon
• 英文别名: 5-chloromethyl-1-methyl-pyrrolidin-2-one；5-(Chloromethyl)-1-methylpyrrolidin-2-one
• CAS: 66769-85-5
• 化学式: C₆H₁₀ClNO
• mdl: MFCD19234224
• 分子量: 147.605
• InChiKey: KSTOZNWYSSCMBN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.4
• 重原子数：
  9
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.833
• 拓扑面积：
  20.3
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  N-Chlor-N-methyl-4-pentencarboxamid 、 无水氯化铬(Ⅱ) 以44%的产率得到
  参考文献：
  名称：

  LESSARD J.; LOTE R.; MACKIEWICZ P.; FURSTOSS R.; WAEGELL B., J. ORG. CHEM, 1978, 43, NO 19, 3750-3756

  摘要：

  DOI：

文献信息

• QUINOLINE AND QUINAZOLINE DERIVATIVES AND THEIR USE AS INHIBITORS OF CYTOKINE MEDIATED DISEASES
  申请人：AstraZeneca AB

  公开号：EP1117653B1

  公开（公告）日：2003-02-05
• CHEMICAL COMPOUNDS
  申请人：AstraZeneca AB

  公开号：EP1117653A1

  公开（公告）日：2001-07-25
• US6593333B1
  申请人：——

  公开号：US6593333B1

  公开（公告）日：2003-07-15
• US6716847B2
  申请人：——

  公开号：US6716847B2

  公开（公告）日：2004-04-06
• [EN] CHEMICAL COMPOUNDS<br/>[FR] COMPOSES CHIMIQUES
  申请人：ZENECA LTD

  公开号：WO2000020402A1

  公开（公告）日：2000-04-13

  The invention concerns amide derivatives of Formula (I), wherein: G is N or CH; R1 is a group such as hydroxy, halo, trifluoromethyl, C¿1-6?alkyl and C1-6alkoxy; each of R?2 and R3¿ is hydrogen, halo, C¿1-6?alkyl, C2-6alkenyl or C2-6alkynyl; R?4¿ is a group such as hydrogen, hydroxy, C¿1-6?alkyl, C1-6alkoxy and C3-7cycloalkyl, or R?4¿ is of the Formula (IC): K J, wherein J is aryl, heteroaryl or heterocyclyl and K is a bond or a group such as oxy and imino, R5 is a group such as hydrogen, halo and trifluoromethyl; m is 1-3 and q is 0-4; or pharmaceutically acceptable salts or in vivo cleavable esters thereof; processes for their preparation, pharmaceutical compositions containing them and their use in the treatment of diseases or medical conditions mediated by cytokines.