(R)-4-(biphenyl-4-yl)-6-methyl-6-(5-methylfuran-2-yl)cyclohexa-1,3-dienecarbaldehyde | 1071780-18-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (R)-4-(biphenyl-4-yl)-6-methyl-6-(5-methylfuran-2-yl)cyclohexa-1,3-dienecarbaldehyde
• CAS: 1071780-18-1
• 化学式: C₂₅H₂₂O₂
• 分子量: 354.448
• InChiKey: FMEJHRWXKSRJRG-RUZDIDTESA-N

反应信息

• 作为产物：
  描述：

  (R)-2-isopropyl-5-methylcyclohexyl 2-((4-(biphenyl-4-yl)-6-methyl-6-(5-methylfuran-2-yl)cyclohexa-1,3-dienyl)methylene)hydrazinecarboxylate 在 硫酸 、 水 作用下， 以 乙醇 为溶剂， 反应 2.5h， 生成 (R)-4-(biphenyl-4-yl)-6-methyl-6-(5-methylfuran-2-yl)cyclohexa-1,3-dienecarbaldehyde
  参考文献：
  名称：

  Synthesis and cellular effects of cycloterpenals: Cyclohexadienal-based activators of neurite outgrowth

  摘要：

  An unusual class of diterpenoid natural products, 'cycloterpenals' ( with a central cyclohexadienal core), that arise in nature by condensation of retinoids and other isoprenes, have been isolated from a variety of organisms including marine sponges as well as from the human eye. A milk whey protein has also demonstrated the formation of a cycloterpenal derived from beta-ionylidineacetaldehyde. Here, we generate a synthetic library of these molecules where we detail reaction conditions required to effect cross condensation of alpha,beta-unsaturated aldehydes as opposed to homodimerization. The ability of this class of molecules to activate neurite outgrowth activity is reported. (C) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2008.07.030