RG-115830 | 755013-59-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: RG-115830
• 英文别名: 3,5-dimethyl-benzoic acid N-(1-tert-butyl-butyl)-N'-(2-ethyl-3-methoxy-benzoyl)-hydrazide；3,5-dimethyl-benzoic acid N-(3,3-dimethyl-1-propyl-butyl)-N'-(2-ethyl-3-methoxy-benzoyl)-hydrazide；Veledimex racemate；N'-(3,5-dimethylbenzoyl)-N'-(2,2-dimethylhexan-3-yl)-2-ethyl-3-methoxybenzohydrazide
• CAS: 755013-59-3
• 化学式: C₂₇H₃₈N₂O₃
• 分子量: 438.61
• InChiKey: LZWZPGLVHLSWQX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.1
• 重原子数：
  32
• 可旋转键数：
  8
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.48
• 拓扑面积：
  58.6
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• Bioavailable diacylhydrazine ligands for modulating the expression of exogenous genes via an ecdysone receptor complex
  申请人：Hormann Eugene Robert

  公开号：US20060020146A1

  公开（公告）日：2006-01-26

  The present invention relates to non-steroidal ligands for use in nuclear receptor-based inducible gene expression system, and a method to modulate exogenous gene expression in which an ecdysone receptor complex comprising: a DNA binding domain; a ligand binding domain; a transactivation domain; and a ligand is contacted with a DNA construct comprising: the exogenous gene and a response element; wherein the exogenous gene is under the control of the response element and binding of the DNA binding domain to the response element in the presence of the ligand results in activation or suppression of the gene.

  本发明涉及用于核受体基于诱导基因表达系统的非甾体配体，以及一种调节外源基因表达的方法，其中包括一个包含：DNA结合结构域；配体结合结构域；转活化结构域；和配体的ecdysone受体复合物与包含外源基因和响应元件的DNA构建物接触；其中外源基因受响应元件控制，并且在配体存在的情况下DNA结合结构域与响应元件结合导致基因的激活或抑制。
• BIOAVAILABLE DIACYLHYDRAZINE LIGANDS FOR MODULATING THE EXPRESSION OF EXOGENOUS GENES VIA AN ECDYSONE RECEPTOR COMPLEX
  申请人：Hormann Eugene Robert

  公开号：US20080064741A1

  公开（公告）日：2008-03-13

  The present invention relates to non-steroidal ligands for use in nuclear receptor-based inducible gene expression system, and a method to modulate exogenous gene expression in which an ecdysone receptor complex comprising: a DNA binding domain; a ligand binding domain; a transactivation domain; and a ligand is contacted with a DNA construct comprising: the exogenous gene and a response element; wherein the exogenous gene is under the control of the response element and binding of the DNA binding domain to the response element in the presence of the ligand results in activation or suppression of the gene.

  本发明涉及用于核受体基础诱导基因表达系统的非类固醇配体，以及一种调节外源基因表达的方法，其中包括将一个包含：DNA结合域、配体结合域、转录激活域和配体的ecdysone受体复合物与一个包含：外源基因和响应元件的DNA构建物接触；其中，外源基因在响应元件的控制下，并且在配合剂存在下，DNA结合域与响应元件结合导致基因的激活或抑制。
• Chiral Diacylhydrazine Ligands for Modulating the Expression of Exogenous Genes via an Ecdysone Receptor Complex
  申请人：HORMANN Robert Eugene

  公开号：US20120116090A1

  公开（公告）日：2012-05-10

  The present invention provides diacylhydrazine ligands and chiral diacylhydrazine ligands for use with ecdysone receptor-based inducible gene expression systems. Thus, the present invention is useful for applications such as gene therapy, large scale production of proteins and antibodies, cell-based screening assays, functional genomics, proteomics, metabolomics, and regulation of traits in transgenic organisms, where control of gene expression levels is desirable. An advantage of the present invention is that it provides a means to regulate gene expression and to tailor expression levels to suit the user's requirements.

  本发明提供了用于基于蜕皮激素受体的诱导基因表达系统的二酰肼配体和手性二酰肼配体。因此，本发明适用于基因治疗、大规模蛋白质和抗体生产、基于细胞的筛选分析、功能基因组学、蛋白质组学、代谢组学和转基因生物特征调控等应用中，其中需要控制基因表达水平。本发明的优点在于提供了一种调节基因表达并根据用户要求定制表达水平的手段。
• Bioavailable Diacylhydrazine Ligands for Modulating the Expression of Exogenous Genes via an Ecdysone Receptor Complex
  申请人：HORMANN Robert Eugene

  公开号：US20130040389A1

  公开（公告）日：2013-02-14

  The present invention relates to non-steroidal ligands for use in nuclear receptor-based inducible gene expression system, and a method to modulate exogenous gene expression in which an ecdysone receptor complex comprising: a DNA binding domain; a ligand binding domain; a transactivation domain; and a ligand is contacted with a DNA construct comprising: the exogenous gene and a response element; wherein the exogenous gene is under the control of the response element and binding of the DNA binding domain to the response element in the presence of the ligand results in activation or suppression of the gene.

  本发明涉及用于核受体基础的可诱导基因表达系统的非类固醇配体，以及一种调节外源基因表达的方法，其中包括：与DNA构建物接触的ecdysone受体复合物，该复合物包括：DNA结合域、配体结合域、转录激活域和配体；其中，外源基因受响应元件控制，DNA结合域在配体存在的情况下与响应元件结合，导致基因的激活或抑制。
• Chiral diacylhydrazine ligands for modulating the expression of exogenous genes via an ecdysone receptor complex
  申请人：Hormann Robert Eugene

  公开号：US20090163592A1

  公开（公告）日：2009-06-25

  The present invention provides diacylhydrazine ligands and chiral diacylhydrazine ligands for use with ecdysone receptor-based inducible gene expression systems. Thus, the present invention is useful for applications such as gene therapy, large scale production of proteins and antibodies, cell-based screening assays, functional genomics, proteomics, metabolomics, and regulation of traits in transgenic organisms, where control of gene expression levels is desirable. An advantage of the present invention is that it provides a means to regulate gene expression and to tailor expression levels to suit the user's requirements.

  本发明提供了用于基于蜕皮激素受体诱导基因表达系统的二酰肼配体和手性二酰肼配体。因此，本发明可用于基因治疗、大规模蛋白质和抗体生产、细胞筛选分析、功能基因组学、蛋白质组学、代谢组学和转基因生物特征调控等应用中，其中需要控制基因表达水平。本发明的优点是提供了一种调节基因表达并根据用户要求调整表达水平的手段。