2-[4-(2-chloro-6-fluoro-benzyloxy)-3-fluoro-phenylcarbamoyl]-cyclopent-1-enecarboxylic acid | 1254036-49-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-[4-(2-chloro-6-fluoro-benzyloxy)-3-fluoro-phenylcarbamoyl]-cyclopent-1-enecarboxylic acid
• 英文别名: 2-[[4-[(2-Chloro-6-fluoro-phenyl)methoxy]-3-fluoro-phenyl]carbamoyl]cyclopentene-1-carboxylic acid；2-[[4-[(2-chloro-6-fluorophenyl)methoxy]-3-fluorophenyl]carbamoyl]cyclopentene-1-carboxylic acid
• CAS: 1254036-49-1
• 化学式: C₂₀H₁₆ClF₂NO₄
• 分子量: 407.801
• InChiKey: SVANOUPJESQBHH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4
• 重原子数：
  28
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  75.6
• 氢给体数：
  2
• 氢受体数：
  6

文献信息

• POLYSUBSTITUTED PYRIDINE COMPOUND, PREPARATION METHOD, USE AND PHARMACEUTICAL COMPOSITION
  申请人：PEKING UNIVERSITY FOUNDER GROUP CO., LTD.

  公开号：US20170029404A1

  公开（公告）日：2017-02-02

  The present invention provides a polysubstituted pyridine compound of Formula I, a preparation method, a use and a pharmaceutical composition thereof. The polysubstituted pyridine compound of Formula I according to the present invention has an excellent anti-tumor effect, can inhibit various cell kinases simultaneously, has significantly excellent pharmacokinetic characteristics, and is very suitable for oral and intravenous administration. The pharmaceutical composition according to the present invention can be useful for treating tumors and cancers.

  本发明提供了一种公式I的多取代吡啶化合物，以及其制备方法、用途和药物组合物。根据本发明，公式I的多取代吡啶化合物具有出色的抗肿瘤效果，可以同时抑制各种细胞激酶，具有显著优异的药代动力学特性，非常适合口服和静脉注射。根据本发明的药物组合物可用于治疗肿瘤和癌症。
• DIHYDROOROTATE-DEHYDROGENASEE INHIBITORS AS VIROSTATIC COMPOUNDS
  申请人：Panoptes Pharma Ges.m.b.H.

  公开号：EP2427186B1

  公开（公告）日：2022-01-12
• COMBINATIONAL THERAPY COMPRISING DHODH INHIBITOR AND METHOTREXATE FOR TREATING AUTOIMMUNE DISEASE
  申请人：4SC AG

  公开号：EP2362771A1

  公开（公告）日：2011-09-07
• ANTI-INFLAMMATORY AGENTS AS VIROSTATIC COMPOUNDS
  申请人：VITT Daniel

  公开号：US20100280081A1

  公开（公告）日：2010-11-04

  The present invention relates to compounds of the general formula (I) and salts and physiologically functional derivatives thereof, for the use as a medicament.
• COMBINATIONAL THERAPY FOR TREATING AUTOIMMUNE DISEASE
  申请人：Gröppel Manfred

  公开号：US20120028985A1

  公开（公告）日：2012-02-02

  The present invention relates to the treatment and prevention of immunological and inflammatory disorders with a compound of formula (I) in combination with methotrexate,