2-[2-[[5-[2-(Dimethylamino)ethylamino]-4,8-dihydroxy-9,10-dioxoanthracen-1-yl]amino]ethyl]guanidine | 1401674-55-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 蒽
• 英文名称: 2-[2-[[5-[2-(Dimethylamino)ethylamino]-4,8-dihydroxy-9,10-dioxoanthracen-1-yl]amino]ethyl]guanidine
• 英文别名: 2-[2-[[5-[2-(dimethylamino)ethylamino]-4,8-dihydroxy-9,10-dioxoanthracen-1-yl]amino]ethyl]guanidine
• CAS: 1401674-55-2
• 化学式: C₂₁H₂₆N₆O₄
• 分子量: 426.475
• InChiKey: OCIXFWYELPLNAM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.7
• 重原子数：
  31
• 可旋转键数：
  8
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  166
• 氢给体数：
  6
• 氢受体数：
  8

反应信息

• 作为产物：
  描述：

  S-甲基异硫脲硫酸盐 、 1-(2-Aminoethylamino)-5-[2-(dimethylamino)ethylamino]-4,8-dihydroxyanthracene-9,10-dione 在 N,N-二异丙基乙胺 作用下， 以 乙醇 为溶剂， 反应 24.0h， 生成 2-[2-[[5-[2-(Dimethylamino)ethylamino]-4,8-dihydroxy-9,10-dioxoanthracen-1-yl]amino]ethyl]guanidine
  参考文献：
  名称：

  SUBSTITUTED ANTHRAQUINONE DYES FOR CELLULAR STAINS AND ENZYME DETECTION

  摘要：

  本发明公开了新的取代蒽醌染料，可能用作细胞染料。在发明的某些方面，核染料可用于染色死亡或固定细胞的细胞核。发明的另一方面涉及包含可由酶转化或切割的酶底物部分的取代蒽醌染料，使得底物部分的转化或切割导致染料的功能性或光谱性质发生可检测的变化。

  公开号：

  US20120252063A1

文献信息

• Substituted Anthraquinone Dyes for Cellular Stains and Enzyme Detection
  申请人：Biotium, Inc.

  公开号：US20150025222A1

  公开（公告）日：2015-01-22

  The invention discloses new substituted anthraquinone dyes that may be useful as cellular stains. In some aspect of the invention, the nuclear stains are useful for staining the nuclei of dead or fixed cells. Another aspect of the invention relates to substituted anthraquinone dyes comprising an enzyme substrate moiety that is transformable or cleavable by an enzyme such that the transformation or cleavage of the substrate moiety causes a detectable change in the functionality or spectral properties of the dye.
• US8790892B2
  申请人：——

  公开号：US8790892B2

  公开（公告）日：2014-07-29
• US9670363B2
  申请人：——

  公开号：US9670363B2

  公开（公告）日：2017-06-06
• [EN] SUBSTITUTED ANTHRAQUINONE DYES FOR CELLULAR STAINS AND ENZYME DETECTION<br/>[FR] COLORANTS ANTHRAQUINONES SUBSTITUÉES UTILES COMME DES COLORANTS CELLULAIRES ET UNE DÉTECTION D'ENZYME
  申请人：BIOTIUM INC

  公开号：WO2012138805A2

  公开（公告）日：2012-10-11

  The invention discloses new substituted anthraquinone dyes that may be useful as cellular stains. In some aspect of the invention, the nuclear stains are useful for staining the nuclei of dead or fixed cells. Another aspect of the invention relates to substituted anthraquinone dyes comprising an enzyme substrate moiety that is transformable or cleavable by an enzyme such that the transformation or cleavage of the substrate moiety causes a detectable change in the functionality or spectral properties of the dye.