| 828911-77-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 酚类
• CAS: 828911-77-9
• 化学式: C₂₂H₂₂N₂O₄
• 分子量: 378.428
• InChiKey: FFBTZOAEBAETTQ-UHFFFAOYSA-N

物化性质

• 沸点：
  591.7±50.0 °C(Predicted)
• 密度：
  1.17±0.1 g/cm3(Predicted)

反应信息

• 作为产物：
  描述：

  curcumin 、 甲基肼 以 溶剂黄146 为溶剂， 反应 6.0h， 生成
  参考文献：
  名称：

  Structure–activity relationship studies of curcumin analogues

  摘要：

  Two series of curcumin analogues, a total of twenty-four compounds, were synthesized and evaluated. The most potent compound, compound 23, showed potent growth inhibitory activities on both prostate and breast cancer lines with IC50 values in sub-micromolar range,fifty times more potent than curcumin. Curcumin analogues might be potential anti-tumor agents for breast and prostate cancers. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2009.01.104