1-(3-chloro-propyl)-2(R),5(R)-trans-dimethyl-pyrrolidine | 868849-51-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯烷类
• 英文名称: 1-(3-chloro-propyl)-2(R),5(R)-trans-dimethyl-pyrrolidine
• 英文别名: (2R,5R)-1-(3-chloropropyl)-2,5-dimethylpyrrolidine
• CAS: 868849-51-8
• 化学式: C₉H₁₈ClN
• 分子量: 175.702
• InChiKey: UGRJIHHEPMVYEN-RKDXNWHRSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  11
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  3.2
• 氢给体数：
  0
• 氢受体数：
  1

文献信息

• 3- Or 4-monosubstituted phenol derivatives useful as H3 ligands
  申请人：Warner-Lambert Company LLC

  公开号：EP1593679A1

  公开（公告）日：2005-11-09

  The invention relates to 3- or 4-monosubstituted phenol derivatives and to processes for the preparation of, intermediates used in the preparation of, compositions containing and the uses of, such derivatives. Said 3- or 4-monosubstituted phenol derivatives are H3 ligands and are useful in numerous diseases, disorders and conditions, in particular inflammatory, allergic and respiratory diseases, disorders and conditions.

  这项发明涉及3-或4-单取代酚衍生物，以及用于制备、制备中间体、含有和使用这些衍生物的过程。所述的3-或4-单取代酚衍生物是H3配体，在许多疾病、紊乱和状况中非常有用，特别是炎症性、过敏性和呼吸系统疾病、紊乱和状况。
• 3- or 4-monosubstituted phenol and thiophenol derivatives useful as H3 ligands
  申请人：Bernardelli Patrick

  公开号：US20050267095A1

  公开（公告）日：2005-12-01

  The invention relates to 3- or 4-monosubstituted phenol and thiophenol derivatives of formula (I) and to processes for the preparation of, intermediates used in the preparation of, compositions containing and the uses of, such derivatives. Said 3- or 4-monosubstituted phenol and thiophenol derivatives are H 3 ligands and are useful in numerous diseases, disorders and conditions, in particular inflammatory, allergic and respiratory diseases, disorders and conditions.

  本发明涉及公式(I)的3-或4-单取代苯酚和硫代苯酚衍生物，以及用于制备这些衍生物的中间体、含有这些衍生物的组合物和这些衍生物的用途的过程。所述的3-或4-单取代苯酚和硫代苯酚衍生物是H3配体，在许多疾病、失调和病况中特别有用，特别是在炎性、过敏和呼吸系统疾病、失调和病况中。
• 3- OR 4-MONOSUBSTITUTED PHENOL AND THIOPHENOL DERIVATIVES USEFUL AS H3 LIGANDS
  申请人：Warner-Lambert Company LLC

  公开号：EP1747210A1

  公开（公告）日：2007-01-31
• US7456164B2
  申请人：——

  公开号：US7456164B2

  公开（公告）日：2008-11-25
• [EN] 3- OR 4-MONOSUBSTITUTED PHENOL AND THIOPHENOL DERIVATIVES USEFUL AS H3 LIGANDS<br/>[FR] DERIVES DE PHENOL ET DE THIOPHENOL 3- OU 4-MONOSUBSTITUES UTILES EN TANT QUE LIGANDS H3
  申请人：WARNER LAMBERT CO

  公开号：WO2005108384A1

  公开（公告）日：2005-11-17

  The invention relates to 3- or 4-monosubstituted phenol and thiophenol derivatives of formula (1) and to processes for the preparation of, intermediates used in the preparation of, compositions containing and the uses of, such derivatives. Said 3- or 4-monosubstituted phenol and thiophenol derivatives are H3 ligands and are useful in numerous diseases, disorders and conditions, in particular inflammatory, allergic and respiratory diseases, disorders and conditions.