2-(Pyrrolidin-1-yl)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)thiazole | 1595285-01-0

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 2-(Pyrrolidin-1-yl)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)thiazole
• 英文别名: 2-pyrrolidin-1-yl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1,3-thiazole
• CAS: 1595285-01-0
• 化学式: C₁₃H₂₁BN₂O₂S
• 分子量: 280.199
• InChiKey: GVZMMMSQSKOKIT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.04
• 重原子数：
  19
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.77
• 拓扑面积：
  62.8
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  5-bromo-2-iodo-N-methyl-6-(N-methylmethylsulfonamido)benzofuran-3-carboxamide 、 2-(Pyrrolidin-1-yl)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)thiazole 在 (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride 、 potassium carbonate 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 1.0h， 以76%的产率得到5-bromo-N-methyl-6-[methyl(methylsulfonyl)amino]-2-(2-pyrrolidin-1-yl-1,3-thiazol-5-yl)-1-benzofuran-3-carboxamide
  参考文献：
  名称：

  Facile functionalization at the C2 position of a highly substituted benzofuran

  摘要：

  To expedite an SAR study of the C2 position of a highly substituted benzofuran ring system, we developed a method for the preparation of a key precursor, iodide 10. From iodide 10, a diverse set of compounds with different substituents at the C2 position were prepared efficiently. (C) 2014 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2014.02.051

文献信息

• Facile functionalization at the C2 position of a highly substituted benzofuran
  作者：Shuwen He、Peng Li、Xing Dai、Casey C. McComas、Chunyan Du、Ping Wang、Zhong Lai、Hong Liu、Jingjun Yin、Paul G. Bulger、Qun Dang、Dong Xiao、Nicolas Zorn、Xuanjia Peng、Ravi P. Nargund、Anandan Palani

  DOI：10.1016/j.tetlet.2014.02.051

  日期：2014.4

  To expedite an SAR study of the C2 position of a highly substituted benzofuran ring system, we developed a method for the preparation of a key precursor, iodide 10. From iodide 10, a diverse set of compounds with different substituents at the C2 position were prepared efficiently. (C) 2014 Elsevier Ltd. All rights reserved.