申请人:O'Shea Paul
公开号:US20060052642A1
公开(公告)日:2006-03-09
This invention describes the reaction of an alpha fluoroalkyl ketone with a bis(trialkylsilyl)amide to give a stable N-trialkylsilyl imine. Treatment of the N-trialkylsilyl imine with an alcohol leads to solvolysis of the trialkylsilyl group and yields a stable mixture of an aminal and an imine in high yield. Catalytic reduction of this mixture, or of the individual components, in the presence of a chiral catalyst leads to a fluoroalkyl amine with high enantioselectivity and high yield.
该发明描述了α-氟烷基酮与双(三烷基硅基)酰胺反应,生成稳定的N-三烷基硅基亚胺。将N-三烷基硅基亚胺与醇处理,可使三烷基硅基团溶解并高产率地生成氨基醛和亚胺的稳定混合物。在手性催化剂存在下,对该混合物或单独的组分进行催化还原,可高选择性和高产率地得到氟烷基胺。