4-methyl-5-(2-morpholin-4-ylethyl)-6-phenyl-2H-pyrazolo[3,4-b]pyridin-3-amine | 1225069-39-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: 4-methyl-5-(2-morpholin-4-ylethyl)-6-phenyl-2H-pyrazolo[3,4-b]pyridin-3-amine
• CAS: 1225069-39-5
• 化学式: C₁₉H₂₃N₅O
• 分子量: 337.425
• InChiKey: JFVWKKFOBWJSLS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  25
• 可旋转键数：
  4
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.37
• 拓扑面积：
  80.1
• 氢给体数：
  2
• 氢受体数：
  5

文献信息

• EPHA4 RTK INHIBITORS FOR TREATMENT OF NEUROLOGICAL AND NEURODEGENERATIVE DISORDERS AND CANCER
  申请人：Rajapakse Hemaka A.

  公开号：US20100113415A1

  公开（公告）日：2010-05-06

  The present invention is directed to compounds of generic formula (I) which are inhibitors of ephrin A4. The invention is also directed to pharmaceutical compositions comprising the compounds, and to the use of the compounds and compositions in the treatment of diseases regulated by the EphA4 RTK signaling, such as neurological and neurodegenerative disorders and cancer.

  本发明涉及一般式(I)的化合物，它们是ephrin A4的抑制剂。该发明还涉及包含这些化合物的药物组合物，以及利用这些化合物和组合物治疗由EphA4 RTK信号调节的疾病，如神经系统和神经退行性疾病以及癌症。