1-(1-(furan-2-yl)ethylidene)-2-(4-p-tolylthiazol-2-yl)hydrazine | 402747-72-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 1-(1-(furan-2-yl)ethylidene)-2-(4-p-tolylthiazol-2-yl)hydrazine
• 英文别名: N-[1-(furan-2-yl)ethylideneamino]-4-(4-methylphenyl)-1,3-thiazol-2-amine
• CAS: 402747-72-2
• 化学式: C₁₆H₁₅N₃OS
• 分子量: 297.381
• InChiKey: FABYHGWSMPCBBC-UHFFFAOYSA-N

物化性质

• 熔点：
  249-250 °C
• 沸点：
  456.1±37.0 °C(predicted)
• 密度：
  1.24±0.1 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  4.55
• 重原子数：
  21.0
• 可旋转键数：
  4.0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  50.42
• 氢给体数：
  1.0
• 氢受体数：
  5.0

反应信息

• 作为产物：
  描述：

  1-(2-furyl)ethanone thiosemicarbazone 、 2-溴-4'-甲基苯乙酮 以 异丙醇 为溶剂， 反应 2.0h， 生成 1-(1-(furan-2-yl)ethylidene)-2-(4-p-tolylthiazol-2-yl)hydrazine
  参考文献：
  名称：

  Synthesis and biological evaluation of novel 2,4-disubstituted-1,3-thiazoles as anti-Candida spp. agents

  摘要：

  A new series of [4-(4'-substituted-phenyl)thiazol-2-yl]hydrazine derivatives were synthesized in good yield (86-99%) and characterized by elemental analysis, IR, H-1 NMR, and mass spectral studies. The compounds were assayed for their in vitro broad-spectrum antifungal activity, compared to clotrimazole and fluconazole, against 20 clinical isolates of pathogenic Candida spp., representing five different species. The results showed that the presence of heterocyclic or bicyclic rings on hydrazone moiety in position C2 of thiazole revealed a promising selective inhibitory activity especially against Candida albicans and Candida glabrata. (C) 2010 Elsevier Masson SAS. All rights reserved,

  DOI：

  10.1016/j.ejmech.2010.10.027