α-Brom-ε-caprolactam | 89580-41-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 内酰胺类
• 英文名称: α-Brom-ε-caprolactam
• 英文别名: 7-Bromoazepan-2-one
• CAS: 89580-41-6
• 化学式: C₆H₁₀BrNO
• 分子量: 192.055
• InChiKey: UQZCMNFSQMWONC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.2
• 重原子数：
  9
• 可旋转键数：
  0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.83
• 拓扑面积：
  29.1
• 氢给体数：
  1
• 氢受体数：
  1

文献信息

• [EN] 1-CARBAMOYLCYCLOALKYLCARBOXYLIC ACID COMPOUNDS, PROCESSES FRO MAKING AND USES THEREOF<br/>[FR] COMPOSES D'ACIDE 1-CARBAMOYLCYCLOALKYLCARBOXYLIQUE, PROCEDES DE FABRICATION ET D'UTILISATION ASSOCIES
  申请人：BOEHRINGER INGELHEIM INT

  公开号：WO2005019158A1

  公开（公告）日：2005-03-03

  The invention relates to the field of pharmaceutics and more specifically to novel cycloalkylamidoacid compositions useful in the preparation of cycloalkyaminoacids and oxazolidinediones, and processes for making cycloamidoacids. Formula (1)

  该发明涉及制药领域，更具体地涉及用于制备环状氨基酸和噁唑烷二酮的新型环状烷基酰胺酸组合物，以及制备环状酰胺酸的方法。公式（1）
• Process for preparing E-isomer of triazolyl styryl ketone derivative
  申请人：SUMITOMO CHEMICAL COMPANY, LIMITED

  公开号：EP0240216A1

  公开（公告）日：1987-10-07

  A novel process for preparing E-isomer of triazolyl styryl ketone derivative of the formula (I): which comprises treating Z-isomer of the said derivative which may contain E-isomer of the said derivative with an acid and an isomerization catalyst in an organic solvent, precipitating and separating the resulting salt of E-isomer from the solution, and decomposing the resulting precipitate to obtain E-isomer of the said derivative free from the acid. Said E-isomer is useful for preparing E-isomer of triazolyl styryl carbinol of the formula (II): which is useful as an antimicrobial, a herbicide, a plant growth regulator, or the like.

  一种制备式(I)三唑基苯乙烯酮衍生物 E-异构体的新工艺： 其中包括在有机溶剂中用酸和异构化催化剂处理可能含有上述衍生物的 E-异构体的上述衍生物的 Z-异构体，从溶液中沉淀和分离得到的 E-异构体盐，并分解得到的沉淀物以获得不含酸的上述衍生物的 E-异构体。所述 E-异构体可用于制备式 (II) 的三唑基苯乙烯基甲醇的 E-异构体： 该衍生物可用作抗菌剂、除草剂、植物生长调节剂等。
• Cyclopentane derivatives
  申请人：GLAXO GROUP LIMITED

  公开号：EP0418007A2

  公开（公告）日：1991-03-20

  The present invention provides the compound [1R-(1β,3α,4β)]-5- [(E)-2-­bromovinyl]-1-[3-hydroxy-4-(hydroxymethyl)-1-cyclopentyl- 2,4(1H,3H)-­pyrimidinedione and salts and solvates and pharmaceutically acceptable derivatives thereof, and describes processes for their preparation, pharmaceutical compositions containing them and their use in the treatment of viral diseases, especially those caused by the Herpetoviridae.

  本发明提供了化合物[1R-(1β,3α,4β)]-5-[(E)-2-溴乙烯基]-1-[3-羟基-4-(羟甲基)-1-环戊基-2,4(1H,3H)-嘧啶二酮及其盐类、溶剂和药学上可接受的衍生物，并描述了它们的制备过程、含有它们的药物组合物以及它们在治疗病毒性疾病，特别是由赫氏病毒科引起的疾病中的用途。
• 1-CARBAMOYLCYCLOALKYLCARBOXYLIC ACID COMPOUNDS, PROCESSES FOR MAKING AND USES THEREOF
  申请人：Boehringer Ingelheim International GmbH

  公开号：EP1656340A1

  公开（公告）日：2006-05-17
• PROCESSES FOR THE PREPARATION OF 3-(4-(2,4-DIFLUOROBENZYLOXY)-3-BROMO-6-METHYL-2-OXOPYRIDIN-1(2H)-YL)-N,4-DIMETHYLBENZAMIDE
  申请人：Pfizer Products Incorporated

  公开号：EP2102161A2

  公开（公告）日：2009-09-23