endo-4-Amino-5-chloro-2-(4-methoxycyclohexyloxy)-N-(8-methyl-8-azabicyclo[3.2.1]oct-3-yl)benzamide hydrochloride | 151102-86-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: endo-4-Amino-5-chloro-2-(4-methoxycyclohexyloxy)-N-(8-methyl-8-azabicyclo[3.2.1]oct-3-yl)benzamide hydrochloride
• 英文别名: 4-amino-5-chloro-2-(4-methoxycyclohexyl)oxy-N-(8-methyl-8-azabicyclo[3.2.1]octan-3-yl)benzamide;hydrochloride
• CAS: 151102-86-2
• 化学式: C₂₂H₃₂ClN₃O₃*ClH
• 分子量: 458.428
• InChiKey: PWAQSRMNXQOECD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.04
• 重原子数：
  30
• 可旋转键数：
  5
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.68
• 拓扑面积：
  76.8
• 氢给体数：
  3
• 氢受体数：
  5

文献信息

• Aminobenzoic acid derivatives
  申请人：Eisai Co., Ltd.

  公开号：EP0554794A1

  公开（公告）日：1993-08-11

  An aminobenzoic acid derivative represented by the following general formulas (I), (I-2) or (I-3), or a pharmacologically acceptable salt thereof, which exhibits a serotonin antagonism and an acetylcholine release accelerating activity at a well-balanced activity ratio and which is efficacious as a drug for patients with gastrointestinal unindentified complaints: and    wherein R¹ represents a group such as an alkynyl or cyanoalkyl group; R² represents a group such as an amino or acylamino group; R³ represents a halogen atom; X represents -O- or -NH-; and A represents an oxygen or sulfur atom.

  一种由以下通式（I）、（I-2）或（I-3）代表的氨基苯甲酸衍生物或其药理上可接受的盐，该衍生物具有5-羟色胺拮抗作用和乙酰胆碱释放加速活性，且活性比非常均衡，可作为胃肠道不明主诉患者的有效药物： 以及 其中，R¹代表炔基或氰基烷基等基团；R²代表氨基或酰氨基等基团；R³代表卤素原子；X代表-O-或-NH-；A代表氧原子或硫原子。
• Novel methods using aminobenzoic acid compounds
  申请人：Barth Jay

  公开号：US20070015789A1

  公开（公告）日：2007-01-18

  The invention provides safe and effective methods for treating and/or preventing gastrointestinal disorders, psychiatric disorders, learning disabilities, Tourette's syndrome, obesity, epilepsy, post-menopausal syndrome, pre-menstrual syndrome, asthma, laryngitis and/or migraines by administering to a patient in need thereof at least one aminobenzoic acid compound. The aminobenzoic acid compound can optionally be administered in combination with other medications that are useful for the disease being treated.
• US5389643A
  申请人：——

  公开号：US5389643A

  公开（公告）日：1995-02-14
• US5599972A
  申请人：——

  公开号：US5599972A

  公开（公告）日：1997-02-04
• US5578603A
  申请人：——

  公开号：US5578603A

  公开（公告）日：1996-11-26