(2S)-2-((S)-phenyl{[2-(trifluoromethyl)phenyl]thio}methyl)morpholine | 668470-57-3

• 分子结构分类: 有机化合物 - 有机硫化合物 - 硫醚类
• 英文名称: (2S)-2-((S)-phenyl{[2-(trifluoromethyl)phenyl]thio}methyl)morpholine
• 英文别名: (2S)-2-((S)-phenyl{[2-(thiomethyl)phenyl]thio}methyl)morpholine；(2S)-2-[(S)-(2-methylsulfanylphenyl)sulfanyl-phenylmethyl]morpholine
• CAS: 668470-57-3
• 化学式: C₁₈H₂₁NOS₂
• 分子量: 331.503
• InChiKey: AQALNWCXYKJNSE-YJBOKZPZSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.7
• 重原子数：
  22
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  71.9
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  (2S)-2-((S)-phenyl{[2-(trifluoromethyl)phenyl]thio}methyl)morpholine 在 盐酸 作用下， 以 乙醚 、 异丙醇 为溶剂， 以78%的产率得到(2S)-2-((S)-phenyl{[2-(trifluoromethyl)phenyl]thio}methyl)morpholine hidrochloride
  参考文献：
  名称：

  [EN] SELECTIVE NOREPINEPHRINE REUPTAKE INHIBITORS FOR THE TREATMENT OF HOT FLASHES, IMPULSE CONTROL DISORDERS AND PERSONALITY CHANGE DUE TO A GENERAL MEDICAL CONDITION
  [FR] TRAITEMENT DES BOUFFEES DE CHALEUR, DES TROUBLES DU CONTROLE DES IMPULSIONS ET DU CHANGEMENT DE PERSONNALITE CONSECUTIFS A UN ETAT PATHOLOGIQUE GENERAL

  摘要：

  公开号：

  WO2005060949A3

文献信息

• 2-(PHENYLTHIOMETHYL)- MORPHOLINE DERIVATIVES FOR USE AS SELECTIVE NOREPINEPHRINE REUPTAKE INHIBITORS
  申请人：ELI LILLY AND COMPANY

  公开号：EP1534291B1

  公开（公告）日：2008-11-12
• Treatment of hot flashes, impulse control disorders and personality change due to a general medical condition
  申请人：Allen John Albert

  公开号：US20070015786A1

  公开（公告）日：2007-01-18

  Selective norepinephrine reuptake inhibitors are useful for the prevention or treatment of hot flashes, vasomotor symptoms, impulse control disorders or personality change due to a general medical condition.
• Treatment of stuttering and other communication disorders with norepinephrine reuptake inhibitors
  申请人：Kelsey Kenneth Douglas

  公开号：US20070032554A1

  公开（公告）日：2007-02-08

  Provided are methods and medicaments for treating stuttering or another communication disorder, comprising administering to a patient in need of such treatment an effective amount of a selective norepinephrine reuptake inhibitor.
• Treatment of learning disabilities and motor skills disorder with norepinephrine reuptake inhibitors
  申请人：Sumner Russell Calvin

  公开号：US20070105960A1

  公开（公告）日：2007-05-10

  Provided are methods and medicaments for treating a learning disability or a Motor Skills Disorder, comprising administering to a patient in need of such treatment an effective amount of a selective norepinephrine reuptake inhibitor.
• US7384941B2
  申请人：——

  公开号：US7384941B2

  公开（公告）日：2008-06-10