2-[Bis(pyridin-2-ylmethyl)amino]acetaldehyde | 947408-21-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 2-[Bis(pyridin-2-ylmethyl)amino]acetaldehyde
• CAS: 947408-21-1
• 化学式: C₁₄H₁₅N₃O
• 分子量: 241.293
• InChiKey: YFAQLARDYASICU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.7
• 重原子数：
  18
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.21
• 拓扑面积：
  46.1
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  4-hydroxy-2-pyridin-2-ylmethyl-1,2,3,4-tetrahydropyrido[1,2-a]pyrazin-5-ylium chloride hydrochloride 在 四甲基胍 作用下， 以 氘代甲醇 为溶剂， 生成 2-[Bis(pyridin-2-ylmethyl)amino]acetaldehyde
  参考文献：
  名称：

  A Reversible pH-Dependent Intramolecular Pyridine−Aldehyde Cyclization

  摘要：

  [GRAPHICS]A dipicolylamine (DPA) attached to an aldehyde moiety cyclizes to form a pyridinium-fused heterocycle. This intramolecular reaction between the pyridine and aldehyde moieties is reversible, and the position of the equilibrium is controlled by pH. The fused-ring heterocycle is stabilized under acidic conditions, whereas the ring-opened form is the major species under basic conditions. The ring-closed form can be utilized as a masked aldehyde precursor to access a variety of functional metal chelators containing the DPA unit.

  DOI：

  10.1021/jo702394v

文献信息

• Sensors for fluorescence and magnetic resonance imaging
  申请人：Zhang Xiao-An

  公开号：US20080138292A1

  公开（公告）日：2008-06-12

  The present invention generally relates to agents and compositions having MRI and/or optical signals, and methods for their use in the determination of an analyte. In some cases, an optical, MRI, or other signal produced by the agent or composition may be affected by the presence of an analyte. Some embodiments of the present invention may provide agents or compositions which are cell permeable. Examples of analytes that may be determined by the present invention include zinc ions, calcium ions, and other biological analytes.

  本发明通常涉及具有MRI和/或光学信号的试剂和组合物，以及其在确定分析物中的使用方法。在某些情况下，试剂或组合物产生的光学、MRI或其他信号可能受到分析物的影响。本发明的一些实施例可能提供可渗透细胞的试剂或组合物。本发明可以确定的分析物的示例包括锌离子、钙离子和其他生物分析物。
• TECHNETIUM-DIPYRIDINE COMPLEXES, AND METHODS OF USE THEREOF
  申请人：Babich John W.

  公开号：US20090023787A1

  公开（公告）日：2009-01-22

  One aspect of the invention relates to novel complexes of technetium (Tc) with various heteroaromatic ligands, e.g., pyridyl and imidazolyl ligands, and their use in radiopharmaceuticals for a variety of clinical diagnostic and therapeutic applications. Another aspect of the invention relates to novel pyridyl ligands that form a portion of the aforementioned complexes. Methods for the preparation of the technetium complexes are also described. Another aspect of the invention relates to novel pyridyl ligands based on derivatized lysine, alanine and bis-amino acids for conjugation to small peptides by solid phase synthetic methods. Additionally, the invention relates to methods for imaging regions of a mammal using the complexes of the invention.

  本发明的一个方面涉及与各种杂环芳香族配体（例如吡啶基和咪唑基配体）形成的铼（Tc）的新型络合物，以及它们在临床诊断和治疗应用中的放射性药物中的使用。本发明的另一方面涉及形成前述络合物一部分的新型吡啶基配体。还描述了制备铼络合物的方法。本发明的另一方面涉及基于衍生的赖氨酸，丙氨酸和双氨基酸的新型吡啶基配体，以通过固相合成方法与小肽结合。此外，本发明涉及使用本发明的络合物对哺乳动物的区域进行成像的方法。
• INHIBITORS OF METALLO-BETA-LACTAMASE (MBL) COMPRISING A ZINC CHELATING MOIETY
  申请人：Universitetet I Oslo

  公开号：EP3052135B1

  公开（公告）日：2018-07-18
• US7875258B2
  申请人：——

  公开号：US7875258B2

  公开（公告）日：2011-01-25
• US8133474B2
  申请人：——

  公开号：US8133474B2

  公开（公告）日：2012-03-13