3-羟基-4-甲氧基-5-硫烷基苯甲酸 | 80547-87-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 3-羟基-4-甲氧基-5-硫烷基苯甲酸
• 中文别名: 5-羟基-3-巯基-4-甲氧基苯甲酸
• 英文名称: 5-hydroxy-3-mercapto-4-methoxybenzoic acid
• 英文别名: 3-hydroxy-4-methoxy-5-sulfanylbenzoic acid
• CAS: 80547-87-1
• 化学式: C₈H₈O₄S
• 分子量: 200.215
• InChiKey: AZIKKAGXVJGGCR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.2
• 重原子数：
  13
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  67.8
• 氢给体数：
  3
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  3-Acetoxy-5-ethoxythiocarbonylsulfanyl-4-methoxy-benzoic acid 在 sodium hydroxide 作用下， 以 水 为溶剂， 反应 3.0h， 生成 3-羟基-4-甲氧基-5-硫烷基苯甲酸
  参考文献：
  名称：

  Catechol O-methyltransferase. 11. Inactivation by 5-hydroxy-3-mercapto-4-methoxybenzoic acid

  摘要：

  5-Hydroxy-3-mercapto-4-methoxybenzoic acid was synthesized as a potential affinity-labeling reagent for catechol O-methyltransferase (COMT, EC 2.1.1.6). This compound was shown to produce noncompetitive inhibition of COMT when assayed in the presence or absence of the reducing agent, dithiothreitol (DTT). If COMT was assayed in the absence of DTT, the compound was shown to be a more potent inhibitor (Kis = 59.9 +/= 15.9 mumol; Kii = 30.2 +/- 5.8 mumol) than if the assays were conducted in the presence of the reducing agent (Kis = 1140 +/- 233 mumol; Kii = 743 +/- 141 mumol). The potent inhibitory effects produced in the absence of DTT could be partially reversed by the addition of DTT to the incubation mixture or by dialysis of the modified enzyme against DTT -containing buffer. These data suggest that in the absence of DTT, 5-hydroxy-3-mercapto-4-methoxybenzoic acid serves as an affinity-labeling reagent for COMT by reaction of the 3-mercapto group of the ligand with an active-site sulfhydryl group. This ligand-protein disulfide bond can be reduced with DTT with subsequent reversal of the inhibitory effects.

  DOI：

  10.1021/jm00345a017

文献信息

• SEMICONDUCTOR DEVICE HAVING QUANTUM DOTS
  申请人：CANON KABUSHIKI KAISHA

  公开号：EP3859804A2

  公开（公告）日：2021-08-04

  A semiconductor device includes an anode (131), a cathode (134), a first functional layer (133B) between the anode and cathode, and a second functional layer (133C) between the first functional layer and the cathode. The first functional layer contains a first quantum dot having a first ligand, and the second functional layer contains a second quantum dot having a second ligand different from the first ligand. The second ligand is an aromatic compound having a sulfide bond and an ester bond.

  一种半导体器件包括阳极（131）、阴极（134）、阳极和阴极之间的第一功能层（133B）以及第一功能层和阴极之间的第二功能层（133C）。第一功能层包含具有第一配体的第一量子点，第二功能层包含具有不同于第一配体的第二配体的第二量子点。第二配体是具有硫化键和酯键的芳香族化合物。
• BORCHARDT, R. T.;HUBER, J. A., J. MED. CHEM., 1982, 25, N 3, 321-323
  作者：BORCHARDT, R. T.、HUBER, J. A.

  DOI：——

  日期：——
• SEMICONDUCTOR DEVICE HAVING QUANTUM DOTS, DISPLAY DEVICE, IMAGING SYSTEM, AND MOVING BODY
  申请人：CANON KABUSHIKI KAISHA

  公开号：US20210242416A1

  公开（公告）日：2021-08-05

  A semiconductor device includes an anode, a cathode, a first functional layer between the anode and cathode, and a second functional layer between the first functional layer and the cathode. The first functional layer contains a first quantum dot having a first ligand, and the second functional layer contains a second quantum dot having a second ligand different from the first ligand. The second ligand is an aromatic compound having a sulfide bond and an ester bond.