3-[7,12,17-Tris-(2-carboxy-ethyl)-3,13-bis-carboxymethyl-8,18-dimethyl-porphyrinogen-2-yl]-propionic acid | 120218-82-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 四吡咯及其衍生物
• 英文名称: 3-[7,12,17-Tris-(2-carboxy-ethyl)-3,13-bis-carboxymethyl-8,18-dimethyl-porphyrinogen-2-yl]-propionic acid
• CAS: 120218-82-8
• 化学式: C₃₈H₄₄N₄O₁₂
• 分子量: 748.787
• InChiKey: SCDDERMQKKPKCA-UHFFFAOYSA-N

反应信息

• 作为产物：
  描述：

  3-[(1Z,4Z,9Z,15Z)-7,12,17-Tris-(2-carboxy-ethyl)-3,13-bis-carboxymethyl-8,18-dimethyl-6,21,22,23-tetrahydro-porphin-2-yl]-propionic acid 在 sodium amalgam 作用下， 以 水 为溶剂， 反应 2.0h， 生成 3-[7,12,17-Tris-(2-carboxy-ethyl)-3,13-bis-carboxymethyl-8,18-dimethyl-porphyrinogen-2-yl]-propionic acid
  参考文献：
  名称：

  Synthesis of substrate analogs of methyltransferases in the vitamin B12 biosynthetic pathway and characterization of their enzymatic products

  摘要：

  The specificity toward substrate analogs of the first two methyltransferases in the vitamin B-12 biosynthetic pathway was probed with 15 synthetic porphyrinogens. Several novel methylated chlorins and isobacteriochlorins were isolated and characterized, suggesting the same methylation sequence C-2 > C-7 > C-20 as for the natural substrate, uro'gen III. The results allow us to narrow down possible structural requirements concerning substrate recognition by the methyltransferase enzymes. (c) 2006 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2006.01.041

文献信息

• Synthetic and biosynthetic studies of porphyrins. Part 8. Syntheses of hepta-, hexa-, and penta-carboxylic porphyrins related to uroporphyrin-I
  作者：Anthony H. Jackson、Damrus Supphayen

  DOI：10.1039/p19870000277

  日期：——

  The title porphyrins, of interest as abnormal metabolites in porphyrin biosynthesis, have been synthesized by the Fischer, and b-oxobilane routes, and compared with the naturally derived materials. Enzymic experiments have shown that the conversion of uroporphyrinogen-I into coproporphyrinogen-I both in vivo and in vitro is non-specific and occurs by both possible pathways via the two intermediate

  标题卟啉，作为卟啉生物合成中的异常代谢产物，已经通过费歇尔和b-氧杂环丁烷路线合成，并与天然物质进行了比较。酶学实验表明，尿卟啉原-I在体内和体外的转化都是非特异性的，并且通过两种中间的六羧酸卟啉原通过两种可能的途径发生。