2-(4-tert-butylbenzyl)-1,3-bis(aminoethylthio)propane | 1140471-58-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-(4-tert-butylbenzyl)-1,3-bis(aminoethylthio)propane
• CAS: 1140471-58-4
• 化学式: C₁₈H₃₂N₂S₂
• 分子量: 340.597
• InChiKey: WPEISGFZOIVMKV-UHFFFAOYSA-N

物化性质

• 沸点：
  494.7±45.0 °C(predicted)
• 密度：
  1.052±0.06 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted)

反应信息

• 作为反应物：
  描述：

  copper(II) perchlorate hexahydrate 、 2-(4-tert-butylbenzyl)-1,3-bis(aminoethylthio)propane 以 乙醇 为溶剂， 以23.5%的产率得到[Cu(2-(4-tert-butylbenzyl)-1,3-bis(aminoethylthio)propane)(H2O)](ClO4)2*H2O
  参考文献：
  名称：

  Synthesis, crystal structures, DNA binding and oxidative cleavage studies of copper(II) complexes of N2S2 tetradentate ligands

  摘要：

  Two new copper(II) complexes with aminothioether ligands, [Cu(L-1)(ClO4)](ClO4) center dot 0.5H(2)O (1) and [Cu(L-2)(H2O)](ClO4)(2) center dot H2O (2) (L-1 = 2-benzyl-1,3-bis(aminoethylthio)propane and L? = 2-(4-butylbenzyl)-1,3-bis(aminoethylthio)propane), have been synthesized and characterized. The single crystal X-ray diffraction analysis reveals that both I and 2 adopt distorted square pyramidal geometries. The binding modes of both complexes with calf thymus DNA were investigated by UV-Vis and CD spectroscopies. The results show that both complexes mainly adopt an electrostatic attraction binding mode with DNA and the binding constants are (1.62 +/- 0.02) x 10(3) and (2.02 +/- 0.02) x 10(3) M-1, respectively. Both complexes are able to cleave pBR322 plasmid DNA efficiently in the presence of ascorbic acid and the activity of 2 is higher than that of 1. The DNA cleavage by I and 2 were inhibited strongly in the presence of DMSO and tert-butyl alcohol, which suggests that hydroxyl radicals are the reactive oxygen species for the cleavage. (C) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.poly.2008.11.057