(3S)-3-(tert-butoxy)pyrrolidinehydrochloride | 2751603-15-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯烷类
• 英文名称: (3S)-3-(tert-butoxy)pyrrolidinehydrochloride
• 英文别名: (3S)-3-[(2-methylpropan-2-yl)oxy]pyrrolidine;hydrochloride
• CAS: 2751603-15-1
• 化学式: C8H18ClNO
• 分子量: 179.69
• InChiKey: FZIWSCKEDNWENP-FJXQXJEOSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.59
• 重原子数：
  11
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  21.3
• 氢给体数：
  2
• 氢受体数：
  2

文献信息

• Process for Production of Benzyloxypyrrolidine Derivative, and Process for Production of Hydrochloride Salt Powder of Optically Active Benzyloxypyrrolidine Derivative
  申请人：Morimoto Masao

  公开号：US20090093643A1

  公开（公告）日：2009-04-09

  Provided are: a process for production of a benzyloxypyrrolidine derivative in high yield and safety, and a process for production of a hydrochloride powder of a benzyloxypyrrolidine derivative in high yield and safety; the process for production of a benzyloxypyrrolidine derivative expressed by the general formula (2) [Chemical formula 2], in reacting a pyrrolidinol derivative represented by the general formula (1) [Chemical formula 1] with a benzyl halide derivative in the presence of an alkali metal hydroxide, wherein the reaction is carried out in either of the following conditions A or B; condition A: an aprotic polar solvent, and condition B: an aliphatic ether solvent containing a phase transfer catalyst:

  提供了一种高产率和安全性的苯甲氧吡咯烷衍生物的生产工艺，以及一种高产率和安全性的苯甲氧吡咯烷衍生物盐酸盐粉末的生产工艺。苯甲氧吡咯烷衍生物的生产工艺由化学式（2）[化学式2]表示，通过在碱金属氢氧化物存在下，用苯甲醇衍生物与苯甲基卤代物反应，反应条件为以下条件A或B之一：条件A为无极性极性溶剂，条件B为含有相转移催化剂的脂肪醚溶剂。
• PROCESS FOR PRODUCTION OF BENZYLOXYPYRROLIDINE DERIVATIVE, AND PROCESS FOR PRODUCTION OF HYDROCHLORIDE SALT POWDER OF OPTICALLY ACTIVE BENZYLOXYPYRROLIDINE DERIVATIVE
  申请人：Toray Fine Chemicals Co., Ltd.

  公开号：EP1950198B1

  公开（公告）日：2014-08-06
• US7772406B2
  申请人：——

  公开号：US7772406B2

  公开（公告）日：2010-08-10