chloromethylcephalosporonic acid chloride | 98265-06-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 内酰胺类
• 英文名称: chloromethylcephalosporonic acid chloride
• 英文别名: (6R,7R)-7-[[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-methoxyiminoacetyl]amino]-3-(chloromethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
• CAS: 98265-06-6
• 化学式: C₁₄H₁₄ClN₅O₅S₂
• 分子量: 431.881
• InChiKey: UAUFVRSUCKBFEX-NDLSKCPHSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.7
• 重原子数：
  27
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  201
• 氢给体数：
  3
• 氢受体数：
  10

反应信息

• 作为反应物：
  描述：

  chloromethylcephalosporonic acid chloride 生成 (6R,7R)-7-[[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-methoxyiminoacetyl]amino]-3-[(3-hydroxy-8-methyl-8-azoniabicyclo[3.2.1]octan-8-yl)methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate
  参考文献：
  名称：

  SAKANEH, KADZUO;YASUDA, SYUSE;NISIMURA, SINTARO;GOTO, DZIRO;INAMOTO, JOSI+

  摘要：

  DOI：

文献信息

• Cross-linked glycopeptide-cephalosporin antibiotics
  申请人：——

  公开号：US20040266666A1

  公开（公告）日：2004-12-30

  This invention provides cross-linked glycopeptide—cephalosporin compounds and pharmaceutically acceptable salts thereof which are useful as antibiotics. This invention also provides pharmaceutical compositions containing such compounds; methods for treating bacterial infections in a mammal using such compounds; and processes and intermediates useful for preparing such compounds.

  这项发明提供了交联的糖肽 - 头孢菌素化合物及其药用盐，可用作抗生素。该发明还提供了含有这种化合物的药物组合物；使用这些化合物治疗哺乳动物细菌感染的方法；以及用于制备这种化合物的过程和中间体。
• Novel antibacterial agents
  申请人：Christensen G. Burton

  公开号：US20070134729A1

  公开（公告）日：2007-06-14

  This invention relates to novel multibinding compounds (agents) that are antibacterial agents. The multibinding compounds of the invention comprise from 2-10 ligands covalently connected by a linker or linkers, wherein each of said ligands in their monovalent (i.e., unlinked) state have the ability to bind to a an enzyme involved in cell wall biosynthesis and metabolism, a precursor used in the synthesis of the bacterial cell wall and/or the bacterial cell surface thereby interfere with the synthesis and/or metabolism of the cell wall. In particular the multibinding compounds of the invention comprise from 2-10 ligands covalently connected by a linker or linkers, wherein each of said ligands has a ligand domain capable of binding to penicillin binding proteins, a transpeptidase enzyme, a substrate of a transpeptidase enzyme, a beta-lactamase enzyme, pencillinase enzyme, cephalosporinase enzyme, a transglycoslase enzyme, or a transglycosylase enzyme substrate; Preferably, the ligands are selected from the beta lactam or glycopeptide class of antibacterial agents.

  本发明涉及一种新型多结合化合物（药剂），其为抗菌剂。该发明的多结合化合物由2-10个配体通过连接剂或连接剂共价连接而成，其中每个单价（即未连接的）配体具有与细胞壁生物合成和代谢中的酶、合成细菌细胞壁和/或细菌细胞表面的前体有结合能力，从而干扰细胞壁的合成和/或代谢。特别地，本发明的多结合化合物由2-10个配体通过连接剂或连接剂共价连接而成，其中每个配体具有能够结合青霉素结合蛋白、横向肽酶酶、横向肽酶酶底物、β-内酰胺酶、青霉素酶、头孢菌素酶、横向转移酶酶或横向转移酶酶底物的配体结构域。优选地，配体选自β-内酰胺类或糖肽类抗菌剂。
• Cross-linked glycopeptide - cephalosporin antibiotics
  申请人：Fatheree R. Paul

  公开号：US20080103299A1

  公开（公告）日：2008-05-01

  This invention provides cross-linked glycopeptide-cephalosporin compounds and pharmaceutically acceptable salts thereof which are useful as antibiotics. This invention also provides pharmaceutical compositions containing such compounds; methods for treating bacterial infections in a mammal using such compounds; and processes and intermediates useful for preparing such compounds.

  本发明提供了交联的糖肽-头孢菌素化合物及其药学上可接受的盐，其可用作抗生素。本发明还提供了含有这种化合物的制药组合物；使用这种化合物治疗哺乳动物细菌感染的方法；以及用于制备这种化合物的过程和中间体。
• CROSS-LINKED GLYCOPEPTIDE-CEPHALOSPORIN ANTIBIOTICS
  申请人：LINSELL Martin S.

  公开号：US20110224130A1

  公开（公告）日：2011-09-15

  This invention provides cross-linked glycopeptide-cephalosporin compounds and pharmaceutically acceptable salts thereof which are useful as antibiotics. This invention also provides pharmaceutical compositions containing such compounds; methods for treating bacterial infections in a mammal using such compounds; and processes and intermediates useful for preparing such compounds.

  本发明提供了交联的糖肽-头孢菌素化合物及其药学上可接受的盐，其可用作抗生素。本发明还提供了含有这种化合物的药物组合物；使用这种化合物治疗哺乳动物细菌感染的方法；以及用于制备这种化合物的过程和中间体。
• US7067481B2
  申请人：——

  公开号：US7067481B2

  公开（公告）日：2006-06-27