(2R)-2-[2-[2-[4-[3-[4-[2-[2-[[(1R)-1-carboxy-3-(phenylmethoxycarbonylamino)propyl]-(4-phenylphenyl)sulfonylamino]oxyethoxy]ethyl]piperazine-1-carbonyl]benzoyl]piperazin-1-yl]ethoxy]ethoxy-(4-phenylphenyl)sulfonylamino]-4-(phenylmethoxycarbonylamino)butanoic acid | 1206631-05-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (2R)-2-[2-[2-[4-[3-[4-[2-[2-[[(1R)-1-carboxy-3-(phenylmethoxycarbonylamino)propyl]-(4-phenylphenyl)sulfonylamino]oxyethoxy]ethyl]piperazine-1-carbonyl]benzoyl]piperazin-1-yl]ethoxy]ethoxy-(4-phenylphenyl)sulfonylamino]-4-(phenylmethoxycarbonylamino)butanoic acid
• CAS: 1206631-05-1
• 化学式: C₇₂H₈₂N₈O₁₈S₂
• 分子量: 1411.62
• InChiKey: GRUYPAIIANHRHW-MSXBASLCSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  100
• 可旋转键数：
  38
• 环数：
  9.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  327
• 氢给体数：
  4
• 氢受体数：
  22

文献信息

• ARYL-SULPHONAMIDIC DIMERS AS METALLOPROTEASES INHIBITORS
  申请人：Rossello Armando

  公开号：US20110124653A1

  公开（公告）日：2011-05-26

  The invention relates to dimeric aryl-sulphonamido compounds endowed with inhibitory activity against metalloproteases MMP, having formula (I) below (M)-L-(M′) (I), wherein M and M′, the same or different from each other, represent the residues of the metalloproteases inhibitors of formula (II), wherein R, R 1 , R 2 , R 3 , G and n have the meanings reported in the specification; the invention also refers to the process for their preparation, to pharmaceutical compositions comprising them and to their use as therapeutic agents, particularly in the treatment of degenerative disorders.