ethyl 7-(2,6-dichlorophenyl)-5-methyl-4,7-dihydrotetrazolo[1,5-a]pyrimidine-6-carboxylate | 1099637-45-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: ethyl 7-(2,6-dichlorophenyl)-5-methyl-4,7-dihydrotetrazolo[1,5-a]pyrimidine-6-carboxylate
• CAS: 1099637-45-2
• 化学式: C₁₄H₁₃Cl₂N₅O₂
• 分子量: 354.196
• InChiKey: MIRKNAWFIUXUKZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4
• 重原子数：
  23
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  78.6
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  5-氨基四氮唑 、 乙酰乙酸乙酯 、 2,6-二氯苯甲醛 在 3-(propylthio)propane-1-sulfonic acid immobilized on silica-coated Fe₃O₄ nanoparticles 作用下， 以 neat (no solvent) 为溶剂， 反应 0.42h， 以98%的产率得到ethyl 7-(2,6-dichlorophenyl)-5-methyl-4,7-dihydrotetrazolo[1,5-a]pyrimidine-6-carboxylate
  参考文献：
  名称：

  3-(丙硫基)丙烷-1-磺酸固定在功能化磁性纳米粒子上，作为一锅合成二氢四唑并[1,5-a]嘧啶和四氢四唑并[5,1-b]喹唑啉酮衍生物的有效催化剂。

  摘要：

  合成了一种高效且可重复使用的催化剂，即固定在功能化磁性纳米粒子[PTPSA@SiO2-Fe3O4]上的3-(丙硫基)丙烷-1-磺酸。首次强调了无溶剂条件下二氢四唑并[1,5-a]嘧啶、二氢四唑并[1,5-a]嘧啶-6-甲酸盐和四氢四唑[5,1]多组分合成的催化活性。 -b]喹唑啉酮类。催化剂的结构通过FT-IR、TGA、SEM-EDX、元素图谱、TEM、VSM和元素分析等表征技术得到了很好的证实。此外，这种独特的催化剂被发现在长达六次循环的情况下有效，这使其成为人们关注的焦点。本方案的优点是催化剂的可回收性、产品的优异收率、反应时间短和反应过程干净。

  DOI：

  10.1039/d2ra03813g

文献信息

• [EN] OPTIONALLY CONDENSED DIHYDROPYRIDINE, DIHYDROPYRIMIDINE AND DIHYDROPYRANE DERIVATIVES ACTING AS LATE SODIUM CHANNEL BLOCKERS<br/>[FR] DÉRIVÉS DE DIHYDROPYRIDINE, DIHYDROPYRIMIDINE ET DIHYDROPYRANE FACULTATIVEMENT CONDENSÉS AGISSANT COMME BLOQUEURS DES CANAUX CALCIQUES TARDIFS
  申请人：CV THERAPEUTICS INC

  公开号：WO2009006580A1

  公开（公告）日：2009-01-08

  The present invention relates to novel heterocyclic compounds and to their use in the treatment of various disease states, including cardiovascular diseases and diabetes. In particular embodiments, the structure of the compounds is given by Formula (I): wherein Q1, Q2, R2, R3, R4, R5, and R6 are as described herein. The invention also relates to methods for the preparation of the compounds, and to pharmaceutical compositions containing such compounds.
• [EN] OPTIONALLY CONDENSED DIHYDRO PYRIDINE, DIHYDROPYRIMIDINE AND DIHYDRO PYRANE DERIVATIVES ACTING AS LATE SODIUM CHANNEL BLOCKERS<br/>[FR] DÉRIVÉS DE DIHYDROPYRIDINE, DE DIHYDROPYRIMIDINE ET DE DIHYDROPYRANE FACULTATIVEMENT CONDENSÉS, JOUANT LE RÔLE DE BLOQUEURS TARDIFS DES CANAUX SODIQUES
  申请人：CV THERAPEUTICS INC

  公开号：WO2010002483A1

  公开（公告）日：2010-01-07

  The present invention relates to novel heterocyclic compounds and to their use in the treatment of various disease states, including cardiovascular diseases and diabetes. In particular embodiments, the structure of the compounds is given by Formula (I): wherein Ql, Q2, R2, R3, R4, R5, and R6 are as described herein. The invention also relates to methods for the preparation of the compounds, and to pharmaceutical compositions containing such compounds.