N-(cyclopropyl(5-(4-ethylsulphanyl-phenyl)pyridin-3-yl)methyl)ethanesulfonamide | 1255869-89-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: N-(cyclopropyl(5-(4-ethylsulphanyl-phenyl)pyridin-3-yl)methyl)ethanesulfonamide
• 英文别名: N-[cyclopropyl-[5-(4-ethylsulfanylphenyl)pyridin-3-yl]methyl]ethanesulfonamide
• CAS: 1255869-89-6
• 化学式: C₁₉H₂₄N₂O₂S₂
• 分子量: 376.544
• InChiKey: XMVKUPHDFZFYEE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  25
• 可旋转键数：
  8
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.42
• 拓扑面积：
  92.7
• 氢给体数：
  1
• 氢受体数：
  5

文献信息

• ARYL PYRIDINE AS ALDOSTERONE SYNTHASE INHIBITORS
  申请人：Chamoin Sylvie

  公开号：US20130035354A1

  公开（公告）日：2013-02-07

  The present invention provides a compound of formula I; a method for manufacturing the compounds of the invention, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.

  本发明提供一种I式化合物；一种制造本发明化合物的方法以及其治疗用途。本发明还提供一种药理活性剂的组合和一种制药组合物。
• METHOD FOR MODIFYING NUCLEIC ACIDS
  申请人：Takara Bio, Inc.

  公开号：EP2669385A1

  公开（公告）日：2013-12-04

  The present invention pertains to: a method for modifying a nucleic acid contained in a sample, said method including a step for bringing the sample into contact with a nucleic acid-modifying agent in the presence of an acidic polysaccharide and/or a nucleotide; and a method for selectively detecting a nucleic acid derived from living cells contained in the sample, said method including the following steps: (a) a step for modifying a nucleic acid contained in a sample according to the method for modifying a nucleic acid contained in a sample, which includes a step for bringing the sample into contact with a nucleic acid-modifying agent in the presence of an acidic polysaccharide and/or a nucleotide; and (b) a step for selectively detecting an unmodified nucleic acid from the sample after step (a). The present invention further pertains to a kit and composition for use in these methods.

  本发明涉及：一种修饰样品中所含核酸的方法，所述方法包括在酸性多糖和/或核苷酸存在的情况下，使样品与核酸修饰剂接触的步骤；以及一种选择性检测样品中所含活细胞衍生核酸的方法，所述方法包括以下步骤：(a) 根据修饰样品中所含核酸的方法，修饰样品中所含核酸的步骤，包括在酸性多糖和/或核苷酸存在的情况下，使样品与核酸修饰剂接触的步骤；以及 (b) 在步骤(a)之后，选择性检测样品中未修饰核酸的步骤。本发明还涉及用于这些方法的试剂盒和组合物。
• US8383827B2
  申请人：——

  公开号：US8383827B2

  公开（公告）日：2013-02-26
• US8519142B2
  申请人：——

  公开号：US8519142B2

  公开（公告）日：2013-08-27
• US8809545B2
  申请人：——

  公开号：US8809545B2

  公开（公告）日：2014-08-19