dimethyl-[1-methyl-1-(4-{5-[6-(6-methyl-pyridin-2-yl)-1H-pyrrolo[2,3-b]pyridin-4-yl]-pyridin-3-yl}-phenyl)-ethyl]-amine | 1171892-24-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: dimethyl-[1-methyl-1-(4-{5-[6-(6-methyl-pyridin-2-yl)-1H-pyrrolo[2,3-b]pyridin-4-yl]-pyridin-3-yl}-phenyl)-ethyl]-amine
• 英文别名: N,N-dimethyl-2-[4-[5-[6-(6-methylpyridin-2-yl)-1H-pyrrolo[2,3-b]pyridin-4-yl]pyridin-3-yl]phenyl]propan-2-amine
• CAS: 1171892-24-2
• 化学式: C₂₉H₂₉N₅
• 分子量: 447.583
• InChiKey: YDUOMNJCGUGKMK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.9
• 重原子数：
  34
• 可旋转键数：
  5
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.21
• 拓扑面积：
  57.7
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• Pyrrolopyrimidines and Pyrrolopyridines
  申请人：Leblanc Catherine

  公开号：US20090181941A1

  公开（公告）日：2009-07-16

  Compounds of formula I in free or salt or solvate form, wherein X, T 1 , T 3 and T 4 have the meanings as indicated in the specification, are useful for treating diseases mediated by the ALK-5 and/or ALK-4 receptor. Pharmaceutical compositions that contain the compounds and processes for preparing the compounds are also described.

  公式I的化合物，无论是游离形式、盐形式还是溶剂化物形式，其中X、T1、T3和T4的含义如说明书中所指，可用于治疗由ALK-5和/或ALK-4受体介导的疾病。还描述了包含这些化合物的药物组合物以及制备这些化合物的方法。
• Tyrosine Derivatives As Ppar-Gamma-Modulators
  申请人：Serra Comas Carmen

  公开号：US20070276043A1

  公开（公告）日：2007-11-29

  Compounds of general formula I, and the salts and solvates thereof, wherein R1 represents the radical 2-benzoylphenylamino; R2 represents —(CH 2 ) s —N(COR 3 )-A-J-T or —(CH 2 ) S —N(R 4 )—B-J-T; and s, R3, R4, A, B, J and T have the meanings disclosed in the description. These compounds are PPARγ modulators and, therefore, are useful for the treatment or prevention of a condition or a disease mediated by these receptors.
• NEW TYROSINE DERIVATIVES AS PPARy MODULATORS
  申请人：SERRA COMAS Carmen

  公开号：US20090088438A1

  公开（公告）日：2009-04-02

  Compounds of general formula I, and the salts and solvates thereof, wherein R1 represents the radical 2-benzoylphenylamino; R2 represents —(CH 2 ) s —N(COR3)-A-J-T or —(CH 2 ) s —N(R4)-B-J-T; and s, R3, R4, A, B, J and T have the meanings disclosed herein. These compounds are PPARγ modulators and, therefore, are useful for the treatment or prevention of a condition or a disease mediated by these receptors.
• US7423172B2
  申请人：——

  公开号：US7423172B2

  公开（公告）日：2008-09-09
• US8314112B2
  申请人：——

  公开号：US8314112B2

  公开（公告）日：2012-11-20