2-(β-Aminoethyl)benzosulfonsaeure | 33048-01-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-(β-Aminoethyl)benzosulfonsaeure
• 英文别名: 2-(2-Aminoethyl)benzenesulfonic acid
• CAS: 33048-01-0
• 化学式: C₈H₁₁NO₃S
• 分子量: 201.246
• InChiKey: ULZFUQPNPXYZMC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -2.3
• 重原子数：
  13
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  88.8
• 氢给体数：
  2
• 氢受体数：
  4

文献信息

• Tripeptide prodrug compounds
  申请人：——

  公开号：US20030181359A1

  公开（公告）日：2003-09-25

  The prodrug of the invention is a modified form of a therapeutic agent and comprises a therapeutic agent, an oligopeptide of three amino acids, a stabilizing group and, optionally, a linker group. The prodrug is cleavable by a trouase enzyme such as Thimet oligopeptidase. Also disclosed are methods of making and using the prodrug compounds.

  本发明的前药是治疗剂的改良形式，包括治疗剂，三个氨基酸的寡肽，稳定基团和可选的连接基团。前药可被Thimet寡肽酶等水解酶酶解。还公开了制备和使用前药化合物的方法。
• Enzyme-cleavable prodrug compounds
  申请人：——

  公开号：US20020142955A1

  公开（公告）日：2002-10-03

  The prodrug of the invention is a modified form of a therapeutic agent and comprises a therapeutic agent, an oligopeptide, a stabilizing group and, optionally, a linker group. The prodrug is cleavable by the enzyme Thimet oligopeptidase, or TOP. Also disclosed are methods of designing prodrugs by utilizing TOP-cleavable sequences within the conjugate and methods of treating patients with prodrugs of the invention.

  本发明的前药是治疗剂的改良形式，包括治疗剂、寡肽、稳定基团和可选的连接基团。该前药可被Thimet寡肽酶或TOP酶水解。本发明还揭示了通过利用共轭物中可被TOP酶水解的序列设计前药的方法以及使用本发明的前药治疗患者的方法。
• Antibodies directed to Clostridium difficile
  申请人：NEUTEC PHARMA PLC

  公开号：EP2261253A2

  公开（公告）日：2010-12-15

  An antibody or an antigen binding fragment thereof comprising the CDR-H3 sequence of: SEQ ID NO: 29 or a sequence having at least 80% homology to SEQ ID NO: 29. The antibody or antigen binding fragment thereof may be used for the treatment or prophylaxis of infection by Clostridium difficile.

  一种抗体或其抗原结合片段，包含 SEQ ID NO: 29 的 CDR-H3 序列或与 SEQ ID NO: 29 具有至少 80% 同源性的序列：该抗体或其抗原结合片段可用于治疗或预防艰难梭菌感染。
• Cysteine protease inhimbitors
  申请人：——

  公开号：US20040198716A1

  公开（公告）日：2004-10-07

  Compounds having quinone and quinone analogs useful for pharmaceutical preparations have now been found which inhibit cysteine proteases, in particular, caspases and 3C-cysteine proteases. The cysteine protease inhibitors of the present invention can be identified by their mode of action in disrupting the ability of cysteine proteases and, in particular, caspases to cleave a peptide chain. These compounds are useful in inhibiting cysteine protease or cysteine protease-like proteins and for treating infections diseases or physiopathological diseases or disorders attributed to the presence of excessive or insufficient levels of cysteine proteases.

  现已发现具有醌和醌类似物的化合物可用于药物制剂，它们可抑制半胱氨酸蛋白酶，特别是caspases和3C-半胱氨酸蛋白酶。本发明的半胱氨酸蛋白酶抑制剂可以通过其破坏半胱氨酸蛋白酶，特别是 Caspase 分裂肽链能力的作用模式来识别。这些化合物可用于抑制半胱氨酸蛋白酶或半胱氨酸蛋白酶样蛋白，治疗因半胱氨酸蛋白酶水平过高或过低而引起的感染性疾病或生理病理疾病或紊乱。
• Process for preparation of of functionalized polyimides
  申请人：Gallucci R. Robert

  公开号：US20060009613A1

  公开（公告）日：2006-01-12

  A method for preparation of a sulfonic and or sulfonic acid salt containing polyimide resins comprising melt reaction of a polyimide resin with an organic compound, wherein the organic compound contains at least one aliphatic primary amine functionality and at least one other functionality selected from the group consisting of sulfonic acids, sulfonic acid salts or mixtures thereof.

  一种制备含磺酸和或磺酸盐的聚酰亚胺树脂的方法，包括聚酰亚胺树脂与有机化合物的熔融反应，其中有机化合物含有至少一种脂肪族伯胺官能团和至少一种其他官能团，这些官能团选自由磺酸、磺酸盐或其混合物组成的组。