2'-{[1-(tert-butoxycarbonyl)cyclopropyl]methoxy}-3-fluorobiphenyl-4-carboxylic acid | 1268842-83-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2'-{[1-(tert-butoxycarbonyl)cyclopropyl]methoxy}-3-fluorobiphenyl-4-carboxylic acid
• 英文别名: 2-Fluoro-4-[2-[[1-[(2-methylpropan-2-yl)oxycarbonyl]cyclopropyl]methoxy]phenyl]benzoic acid
• CAS: 1268842-83-6
• 化学式: C₂₂H₂₃FO₅
• 分子量: 386.42
• InChiKey: ROPKJYVFDFNEQW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.3
• 重原子数：
  28
• 可旋转键数：
  8
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  72.8
• 氢给体数：
  1
• 氢受体数：
  6

文献信息

• Phosphoramidates of monosaccharides
  申请人：Bioiberica, S.A.

  公开号：EP2471802A1

  公开（公告）日：2012-07-04

  The present invention relates novel phosphoramidates of monosaccharides of formula (I), wherein R1 is a monosaccharide group selected from A and B; R2, R3, R4, R5, R6, R7, R8, R9, R10, R11, R12, R13, R14, R15, R16 and X are as defined herein. Preferably X is -O-. The present invention also provides processes for the production of compounds of formula (I), pharmaceutical compositions comprising these compounds, as well as to the use thereof in medical therapy, preferably in the treatment of osteoarthritis. wherein: R1 is selected from A and B,

  本发明涉及公式(I)的单糖磷酰胺的新型磷酸酰胺，其中R1是从A和B中选择的单糖基团；R2、R3、R4、R5、R6、R7、R8、R9、R10、R11、R12、R13、R14、R15、R16和X如本文所定义。优选X为-O-。本发明还提供了制备公式(I)化合物的方法，包括含有这些化合物的药物组合物，以及在医学治疗中的使用，优选用于骨关节炎的治疗。其中：R1从A和B中选择。
• 3-(BIARYOXY)PROPIONIC ACID DERIVATIVE
  申请人：Nishi Tatsuya

  公开号：US20120245152A1

  公开（公告）日：2012-09-27

  A compound of the general formula (I): [wherein, R 1 represents a halogen atom, or the like, R 2 represents a hydrogen atom, or the like, R 3 and R 4 , each independently, represent a hydrogen atom, a C 1-4 alkyl group, or the like, R 5 represents a hydrogen atom, a halogen atom, or the like, R 6 represents a hydrogen atom, a halogen atom, or the like, R 7 and R 8 , each independently, represent a hydrogen atom, a halogen atom, or the like, R 9 and R 10 , each independently, represent a hydrogen atom, a C 1-4 alkyl group, R 11 and R 12 , each independently, represent a hydrogen atom, a C 1-4 alkyl group, or the like, X represents an oxygen atom, a group —CH 2 —, or the like, Y represents a nitrogen atom, a group ═CH—, or the like, and Z represents a nitrogen atom, or the like] or a pharmacologically acceptable salt thereof, which has an excellent suppressive action on platelet aggregation, and is useful for prevention and/or treatment of thromboembolism.

  一种具有一般式（I）的化合物：[其中，R1代表卤素原子或类似物，R2代表氢原子或类似物，R3和R4各自独立地代表氢原子、C1-4烷基或类似物，R5代表氢原子、卤素原子或类似物，R6代表氢原子、卤素原子或类似物，R7和R8各自独立地代表氢原子、卤素原子或类似物，R9和R10各自独立地代表氢原子、C1-4烷基，R11和R12各自独立地代表氢原子、C1-4烷基或类似物，X代表氧原子、-CH2-基团或类似物，Y代表氮原子、═CH-基团或类似物，Z代表氮原子或类似物]或其药学上可接受的盐，具有出色的抑制血小板聚集作用，可用于预防和/或治疗血栓栓塞。
• 3-(BIARYLOXY) PROPIONIC ACID DERIVATIVE
  申请人：Daiichi Sankyo Company, Limited

  公开号：EP2471792A1

  公开（公告）日：2012-07-04

  A compound of the general formula (I): [wherein, R1 represents a halogen atom, or the like, R2 represents a hydrogen atom, or the like, R3 and R4, each independently, represent a hydrogen atom, a C1-4 alkyl group, or the like, R5 represents a hydrogen atom, a halogen atom, or the like, R6 represents a hydrogen atom, a halogen atom, or the like, R7 and R8, each independently, represent a hydrogen atom, a halogen atom, or the like, R9 and R10, each independently, represent a hydrogen atom, a C1-4 alkyl group, R11 and R12, each independently, represent a hydrogen atom, a C1-4 alkyl group, or the like, X represents an oxygen atom, a group -CH2-, or the like, Y represents a nitrogen atom, a group =CH-, or the like, and Z represents a nitrogen atom, or the like] or a pharmacologically acceptable salt thereof, which has an excellent suppressive action on platelet aggregation, and is useful for prevention and/or treatment of thromboembolism.

  通式(I)的化合物： [其中，R1 代表卤原子或类似物，R2 代表氢原子或类似物，R3 和 R4 各自独立地代表氢原子、C1-4 烷基或类似物，R5 代表氢原子、卤原子或类似物，R6 代表氢原子、卤原子或类似物，R7 和 R8 各自独立地代表氢原子、卤原子或类似物，R9 和 R10 各自独立地代表氢原子、R11和R12各自独立地代表氢原子、C1-4烷基或类似基团，X代表氧原子、基团-CH2-或类似基团，Y代表氮原子、基团=CH-或类似基团，Z代表氮原子或类似基团]或其药理上可接受的盐，对血小板聚集有很好的抑制作用，可用于预防和/或治疗血栓栓塞。
• US8729095B2
  申请人：——

  公开号：US8729095B2

  公开（公告）日：2014-05-20